Structural Biology of DNA Damage and Repair

Buch | Hardcover

138 Seiten

2011
Oxford University Press Inc (Verlag)
978-0-8412-2574-9 (ISBN)

Keine Verlagsinformationen verfügbar

Artikel merken

The human genome is continuously exposed to many classes of genotoxins. Of these, three that will be discussed herein include 5,6-dihydroxy-5,6- dihydrothymine (thymine glycol; Tg), O6-methylguanine (O6MeG), and benzo[a]pyrene. In all cases, if the genome is not repaired, these and other genotoxic lesions precipitate serious biological consequences, including altered gene expression, mutation, and cell death. In addition to the genotoxic responses, it is increasingly
being recognized that DNA lesions can alter the epigenetic profiles that are imprinted by naturally occurring DNA modifications.

The impetus for this volume came from a recent symposium sponsored by the ACS Division of Chemical Toxicology, bringing together scientists interested in the synthesis and structures of site-specific DNA adducts and in mechanistic aspects of DNA repair. This volume presents work at the interface between the structural biology of DNA damage and DNA repair.

Michael P. Stone is Professor & Department Chairman of the Department of Chemistry at Vanderbuilt University.

PREFACE; MICHAEL P. STONE; KYLE L. BROWN, MARINA ROGINSKAYA, YUE ZOU, ALVIN ALTAMIRANO, ASHIS K. BASU, AND MICHAEL P. STONE; EMILY H. RUBINSON, SURAJ ADHIKARY, AND BRANDT F. EICHMAN; JOSHUA I. FRIEDMAN AND JAMES T. STIVERS; STEVEN M. SHELL AND WALTER J. CHAZIN; REBECCA GUZA, ANTHONY E. PEGG, AND NATALIA TRETYAKOVA; ELIZAVETA S. GROMOVA, OKSANA M. SUBACH, VLADIMIR B. BASKUNOV, AND NICHOLAS E. GEACINTOV; INDEXES; AUTHOR INDEX; SUBJECT INDEX

Reihe/Serie	ACS Symposium Series ; 1041
Zusatzinfo	35 b&w illus
Verlagsort	New York
Sprache	englisch
Maße	158 x 232 mm
Gewicht	352 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-8412-2574-5 / 0841225745
ISBN-13	978-0-8412-2574-9 / 9780841225749
Zustand	Neuware