Nuclear Receptors
Oxford University Press (Verlag)
978-0-19-963742-3 (ISBN)
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The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is
guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a
model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.
Preface ; Table of Contents ; List of Contributors ; 1. Evolutionary biology of the nuclear receptor superfamily ; 2. Initial characterization of new orphan receptors ; 3. Adopting orphans: finding ligands ; 4. Kinetic analysis of nuclear receptor interactions ; 5. Functional characterization of coactivators using mammalian cell microinjection ; 6. Analysis of steroid/nuclear receptor phosphorylation ; 7. Ligand- and cofactor-regulated transcription with chromatin templates ; 8. Hormone resistance syndromes ; 9. In Vitro assembly of steroid receptor - Hsp90 complexes ; 10. Yeast as a system for the study of nuclear receptor function ; 11. Regulation of heterologus proteins by fusion to a hormone binding domain ; List of non-standard Abbreviations ; List of suppliers ; Appendices
| Reihe/Serie | Practical Approach Series ; 207 |
|---|---|
| Zusatzinfo | numerous halftones and line figures |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 163 x 219 mm |
| Gewicht | 445 g |
| Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
| Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik ► Medizintechnik | |
| ISBN-10 | 0-19-963742-3 / 0199637423 |
| ISBN-13 | 978-0-19-963742-3 / 9780199637423 |
| Zustand | Neuware |
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