Design and Analysis of DNA Microarray Investigations

Richard M. Simon, Edward L. Korn, Lisa M. McShane, Michael D. Radmacher, George W. Wright (Autoren)

Buch | Softcover

200 Seiten

2011
Springer-Verlag New York Inc.
978-1-4419-1802-4 (ISBN)

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DNA microarrays are an important technology for studying gene expression. With a single hybridization, the level of expression of thousands of genes, or even an entire genome, can be estimated for a sample of cells. Consequently, manylaboratoriesareattemptingtoutilizeDNAmicroarraysintheirresearch. Whereaslaboratoriesarewellpreparedtoaddressthesigni?cantexperimental challenges in obtaining reproducible data from this RNA-based assay, inv- tigators are less prepared to analyze the large volumes of data produced by DNA microarrays. Although many software packages have been developed for the analysis of DNA microarray data, software alone is insu?cient. One needs knowledge aboutthevariousaspectsofdataanalysisinordertoselectandutilizesoftware e?ectively. There is a plethora of analysis methods being published and it is di?cult for biologists to determine which methods are valid and appropriate for their problems. Many scientists have learned that software is not an adequate substitute for biostatistical knowledge and seek statistical collaborators. Unfortunately, there is presently a shortage of statisticians who are available and knowled- able about DNA microarrays. For statisticians to be e?ective collaborators in anyarea,theymustinvestthetimetounderstandthesubjectmatterareaand become familiar with the literature so that they can ask the right questions and identify the key issues. Our objectives in this book are twofold: to provide scientists with infor- tion about the design and analysis of studies using DNA microarrays that will enable them to plan and analyze their own studies or to work with statistical collaborators e?ectively, and to aid statistical and computational scientists wishing to develop expertise in this area.

DNA Microarray Technology.- Design of DNA Microarray Experiments.- Image Analysis.- Quality Control.- Array Normalization.- Class Comparison.- Class Prediction.- Class Discovery.

Reihe/Serie	Statistics for Biology and Health
Zusatzinfo	19 Illustrations, color; 39 Illustrations, black and white; X, 200 p. 58 illus., 19 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Mathematik / Informatik ► Informatik ► Theorie / Studium
	Mathematik / Informatik ► Mathematik
	Medizin / Pharmazie ► Gesundheitswesen
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-4419-1802-7 / 1441918027
ISBN-13	978-1-4419-1802-4 / 9781441918024
Zustand	Neuware