Structural Biology Using Electrons and X-rays

An Introduction for Biologists

Buch | Softcover

450 Seiten

2011
Academic Press Inc (Verlag)
978-0-12-370581-5 (ISBN)

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Provides an accessible introduction to the two major diffraction-based techniques of structural biology. This title gives an account of the methods adapted to crystals, helices, viral heads, and single particles.

Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen’s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles).

This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics.

Part I: Fourier Transforms

1. Overview

2. Correlations & Convolutions

3. Fourier Fundamentals

4. Digital Fourier Transforms

5. Filters

6. Two-Dimensional FTs

Part II: Optics

7. Microscopy with Rays

8. Waves

9. Wave Imaging

Part III: Further Mathematical Methods/General Aspects

10. Symmetry

11. Statistics & Matrices

12. The Third Dimension

Part IV: Image Analysis/Structure Determination

13. Special Symmetries

14. Crystalline Sheets

15. Helices

16. Icosahedral Particles

17. Unsymmetrical ("Single") Particles

18. Distortion Correction

19. FT Mathematics

20. Elementary Matrices

Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	920 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-12-370581-9 / 0123705819
ISBN-13	978-0-12-370581-5 / 9780123705815
Zustand	Neuware