Bioinformatics

Volume II: Structure, Function and Applications

Buch | Softcover

506 Seiten

2011 | Softcover reprint of hardcover 1st ed. 2008
Humana Press Inc. (Verlag)
978-1-61737-895-9 (ISBN)

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Not only is the quantity of life science data expanding, but new types of biological data continue to be introduced as a result of technological development and a growing understanding of biological systems. Methods for analyzing these data are an increasingly important component of modern biological research. In Bioinformatics, leading researchers in the field provide a selection of the most useful and widely applicable methods, able to be applied as is, or with minor variations, to many specific problems. Volume II: Structure, Function and Applications contains methods pertinent to the prediction of protein and RNA structures and the analysis and classification of structures, methods for inferring the function of previously identified genomic elements, chiefly protein-coding genes, medical applications in diagnostics and drug discovery, and "meta-methods" for developers of bioinformatics algorithms.

Structures.- UNAFold.- Protein Structure Prediction.- An Introduction to Protein Contact Prediction.- Analysis of Mass Spectrometry Data in Proteomics.- The Classification of Protein Domains.- Inferring Function.- Inferring Function from Homology.- The Rosetta Stone Method.- Inferring Functional Relationships from Conservation of Gene Order.- Phylogenetic Profiling.- Phylogenetic Shadowing.- Prediction of Regulatory Elements.- Expression and Microarrays.- Identifying Components of Complexes.- Integrating Functional Genomics Data.- Applications and Disease.- Computational Diagnostics with Gene Expression Profiles.- Analysis of Quantitative Trait Loci.- Molecular Similarity Concepts and Search Calculations.- Optimization of the MAD Algorithm for Virtual Screening.- Combinatorial Optimization Models for Finding Genetic Signatures from Gene Expression Datasets.- Genetic Signatures for a Rodent Model of Parkinson's Disease Using Combinatorial Optimization Methods.- Analytical and Computational Methods.- Developing Fixed-Parameter Algorithms to Solve Combinatorially Explosive Biological Problems.- Clustering.- Visualization.- Constructing Computational Pipelines.- Text Mining.

Erscheint lt. Verlag	26.5.2011
Reihe/Serie	Methods in Molecular Biology ; 453
Zusatzinfo	3 Illustrations, color; 117 Illustrations, black and white; XIV, 506 p. 120 illus., 3 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	193 x 260 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Mathematik / Informatik ► Mathematik
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-61737-895-X / 161737895X
ISBN-13	978-1-61737-895-9 / 9781617378959
Zustand	Neuware