Regulation of microRNAs

Buch | Hardcover

160 Seiten

2010
Springer-Verlag New York Inc.
978-1-4419-7822-6 (ISBN)

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Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.

Helge Großhans, PhD is a research group leader at the Friedrich Miescher Institute for Biomedical Research (FMI), which is part of the Novartis Research Foundation in Basel, Switzerland. His main research interests are in the developmental function, regulation, and mechanism of action of microRNAs. He received his PhD from the University of Heidelberg and did his postdoctoral training at Yale University. He is the winner of a 2009 ERC Award.

microRNA Biogenesis and Function.- Regulation of pri-miRNA Processing Through Smads.- Stimulation of pri-miR-18a Processing by hnRNP A1.- KSRP Promotes the Maturation of a Group of miRNA Precuresors.- Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor.- Autoregulatory Mechanisms Controlling the Microprocessor.- Regulation of pre-miRNA Processing.- The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function.- miRNAs Need a Trim.- Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression.- Turnover of Mature miRNAs and siRNAs in Plants and Algae.- MicroRNases and the Regulated Degradation of Mature Animal miRNAs.

Reihe/Serie	Advances in Experimental Medicine and Biology ; 700
Zusatzinfo	6 Illustrations, color; 29 Illustrations, black and white; XVI, 160 p. 35 illus., 6 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-4419-7822-4 / 1441978224
ISBN-13	978-1-4419-7822-6 / 9781441978226
Zustand	Neuware