Genome Instability & Transgenerational Effects
Nova Science Publishers Inc (Verlag)
978-1-60876-831-8 (ISBN)
Genome stability of every species depends on complex interaction of predefined and environmentally induced genetic and epigenetic states. Predefined states consist of chromatin structure and cell metabolic processes such as DNA repair, radical scavenging and cell signalling, whereas induced states depend on interactions with the environment. Organisms are able to respond to a changing environment by various alterations in their somatic cells as well as in their germline and progeny. In this book, we will describe various phenomena associated with the maintenance of genome stability. These include genetic and epigenetic responses to various stresses in exposed cells and organisms, bystander and, bystander-like effects, transgenerational changes in genome stability and stress tolerance in bacteria, plants and animals.
Genetic & epigenetic regulation of transgenerational changes in genome stability: an overview; Genetic & epigenetic mechanisms ensuring stability of mammalian genomes; Genetic & epigenetic regulation of genome stability in plants; Evolution of the Fpg/Nei family of DNA glycosylases; Stress-induced mutagenesis in bacteria; Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) loci as an example of bacterial adaptive immunity against phages; White tail tip inheritance in mice: from the "Kit locus" to a new mode of heredity; Role of epigenetic changes in the non-targeted radiation-induced effects: understanding the epigenetics of bystander & transgenerational effects; A review of tandem repeat sequences: Markers of genetic instability; Transgenerational genome instability in fish; Germ cell-mediated mutagenesis: insights from the transgenic medaka; Transgenerational genomic instability in mammals; The epigenetic (re)programming of phenotypic differences in behavior; Lifestyle factors, epigenetic abnormalities, & genomic instability: implications for carcinogenesis; Paramutations in plants; Transgenerational response to stress in plants involves genome destabilization, changes in methylation & increase in stress tolerance; Plant transposable elements & plasticity of host genomes: the stress connection; Intra- & interplant stress signalling: bystander-like effects found in plants; Systemic heuristic approaches guide the interaction of enhanced genetic diversity & complex stresses to generate better wheat germplasm faster & at lower cost; Index.
| Erscheint lt. Verlag | 1.7.2010 |
|---|---|
| Zusatzinfo | Illustrations, unspecified |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 260 x 180 mm |
| Gewicht | 960 g |
| Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 1-60876-831-7 / 1608768317 |
| ISBN-13 | 978-1-60876-831-8 / 9781608768318 |
| Zustand | Neuware |
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