Archibald Garrod and the Individuality of Man
Seiten
1993
Clarendon Press (Verlag)
978-0-19-262145-0 (ISBN)
Clarendon Press (Verlag)
978-0-19-262145-0 (ISBN)
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Archibald Garrod is chiefly remembered as the originator of the concept of inborn errors of metabolism, based on his studies of inherited biochemical diseases. Throughout his life, he developed and propounded his ideas about biochemical individuality. This is a study of his life and work.
Archibald Garrod is chiefly remembered as the originator of the concept of inborn metabolic error, an idea which grew from his studies of families with diseases whose biochemical basis he was able to identify. He was recognized for his achievement in his own lifetime and held a respected position in the medical establishment, a position accorded to him on the basis of his scientific achievement rather than for any great clinical skill. But to concentrate on the concept of inborn errors is to overlook what has turned out to be Garrod's greatest achievement, for it was he who first saw that genetics, biochemistry, and medicine are fundamentally linked. He propounded, to all who would listen, his thesis that disease can only be properly studies in the light of an individual's genetic susceptibility, and that that in turn rests on biochemical individuality. Only by thinking of human diseases as the consequence of genetic and environmental interaction are the advances of today's and tomorrow's medicine possible. In this scholarly biography, Alexander G.
Bearn, himself a physician and a scientist in the Garrodian tradition, has drawn a portrait of one of the great minds of 20th century medicine.
Archibald Garrod is chiefly remembered as the originator of the concept of inborn metabolic error, an idea which grew from his studies of families with diseases whose biochemical basis he was able to identify. He was recognized for his achievement in his own lifetime and held a respected position in the medical establishment, a position accorded to him on the basis of his scientific achievement rather than for any great clinical skill. But to concentrate on the concept of inborn errors is to overlook what has turned out to be Garrod's greatest achievement, for it was he who first saw that genetics, biochemistry, and medicine are fundamentally linked. He propounded, to all who would listen, his thesis that disease can only be properly studies in the light of an individual's genetic susceptibility, and that that in turn rests on biochemical individuality. Only by thinking of human diseases as the consequence of genetic and environmental interaction are the advances of today's and tomorrow's medicine possible. In this scholarly biography, Alexander G.
Bearn, himself a physician and a scientist in the Garrodian tradition, has drawn a portrait of one of the great minds of 20th century medicine.
The family; growing up; a career on the move - Oxford and London; the postgraduate years; Alkaptonuria - the clinical clue; a career caught in controversy; the Croonian lectures - a scientific landmark; Malta - the war years; the call to Oxfordl the Regius professor; creativity in retirement; one gene - one enzyme; a summing up. Appendix: Sir Archibald Garrod's antecedents.
| Erscheint lt. Verlag | 1.4.1993 |
|---|---|
| Co-Autor | Michael S. Brown, Joseph L. Goldstein |
| Zusatzinfo | frontispiece, halftones, line drawings, bibliography |
| Verlagsort | Oxford |
| Sprache | englisch |
| Themenwelt | Literatur ► Biografien / Erfahrungsberichte |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| ISBN-10 | 0-19-262145-9 / 0192621459 |
| ISBN-13 | 978-0-19-262145-0 / 9780192621450 |
| Zustand | Neuware |
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