Microstructure with Magnetic Resonance

Problems and Solutions

Valerij G. Kiselev, Dmitry S. Novikov (Autoren)

Buch | Softcover

250 Seiten

2025
Academic Press Inc (Verlag)
978-0-12-822469-4 (ISBN)

Noch nicht erschienen (ca. April 2025)
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Microstructure with Magnetic Resonance: Problems and Solutions responds to the challenge of how to see the invisible with magnetic resonance imaging. Technically, the goal is to quantify cellular-level properties of biological tissues and microarchitecture of porous media orders of magnitude below the achievable resolution of MR. While the interest in this area has grown exponentially, current research involves physics outside the scope of standard NMR and MRI textbooks. Microstructure with Magnetic Resonance: Problems and Solutions introduces readers to methods of describing complex media in statistical terms, and covers the effects of complex microenvironments on the MR signal phase, on the transverse relaxation, and on different facets of the diffusion-weighted signal.The book presents the material as a set of problems with detailed solutions, that build on each other, stimulating a hands-on approach to learning. Each chapter begins with a short introduction to the topic, followed by problems, solutions, and a summary of key points. The problems start from the basics, and bring the reader step-by-step to the frontier of current knowledge. The overall focus is on gaining physical insight, by drawing on simple physical analogies and dimensional analysis, which help to reproduce the essence of the results obtained in classical and recent studies. The necessary mathematics is collected in dedicated appendices.With this book the reader will:• Understand the classic and current literature on microstructure mapping with NMR and MRI• Become familiar with the modern trends in microstructure MR• Be able to design new experiments using MR based on a solid theoretical foundation

Dr. Kiselev joined the field of MRI with a decade-long research experience in quantum field theory including authoring a textbook on this subject. His current focus is on understanding how the microstructure of biological tissues is imprinted in the observable MRI signal obtained with dedicated MRI techniques. His contributions include quantification of perfusion measurements using DSC MRI, vessel size imaging, and the effective medium approach to transverse relaxation and diffusion with the goal to quantify the cellular tissue microarchitecture. He has organized numerous educational events on diffusion and perfusion MRI, where he introduced the problem-solving approach. Dr. Novikov brings a decade of experience in theoretical condensed matter physics to the biomedical MRI. He is developing analytical tools and parameter estimation methods to quantify cellular-level tissue structure and its changes in disease based on various MRI contrasts. His contributions include the effective medium approach for diffusion and relaxation to quantify cell density, their packing arrangement, membrane permeability and other related metrics, with the goal to identify quantitative disease biomarkers in neurodegenerative diseases, tumors and myopathies. He introduced the problem-solving approach to the ISMRM educational sessions.

ForewordUnits, conventions, notations1. Diffusion basics2. First touch of microstructure3. Describing randomness: Correlation functions4. Representing rotations5. NMR basics6. The induced field and spin phase7. Relaxation8. Physics of diffusion measurement9. The cumulant expansion and velocity autocorrelation function10. Diffusion beyond the Gaussian phase approximation11. Diffusion in three dimensions12. Multiple Gaussian compartments13. Advanced diffusion encoding14. Diffusion and Bloch–Torrey equations15. Impermeable interfaces and porous media16. Permeable interfaces and heterogeneous media17. Transverse relaxation in dilute suspensions18. Monte Carlo simulationsAftermath: Math facts, tricks and hacks

Erscheint lt. Verlag	1.4.2025
Reihe/Serie	Advances in Magnetic Resonance Technology and Applications
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Geisteswissenschaften ► Psychologie ► Allgemeine Psychologie
	Geisteswissenschaften ► Psychologie ► Biopsychologie / Neurowissenschaften
	Geisteswissenschaften ► Psychologie ► Verhaltenstherapie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	0-12-822469-X / 012822469X
ISBN-13	978-0-12-822469-4 / 9780128224694
Zustand	Neuware