Understanding Radiation Biology

From DNA Damage to Cancer and Radiation Risk

Buch | Hardcover

16 Seiten

2019
CRC Press (Verlag)
978-0-367-25515-2 (ISBN)

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This textbook provides a exploration into the action of radiation, taking readers into the cell and discussing the damage and the consequences of radiation exposure to living matter. This book will provide the foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, and medicine.

This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose–effect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography.

Features

Presents a comprehensive insight into radiation action on living matter

Contains important implications for radiological protection and regulations

Provides analytical methods for applications in radiotherapy

Dr. K. H. Chadwick, now retired, worked as a research scientist in the Netherlands before moving to Belgium to manage research contracts on radiation biological effects in the Euratom Radiation Protection Research Programme of the European Commission in Brussels. He also served on the editorial board of the Journal for Radiological Protection for 10 years and is a fellow of the Institute of Physics (FInst P) and the Society for Radiological Protection (FSRP).

PART I: Ionising Radiation Effects. 1. The Molecular Model and DNA Double Strand Breaks. 2. The Molecular Model for Cellular Effects. 3. The Link from Molecular Lesion to Cellular Effects. 4. DNA Double Strand Breaks and Chromosomal Aberrations. 5. The Effect of Dose Rate, Fractionation and Post-Irradiation Repair. 6. Radiation Quality. 7. Radiation-Induced Cancer. 8. Radiation-Induced Lethality. 9 Radiological Protection. PART II: Ultraviolet Light Effects. 10. The Molecular Model for the Cytotoxic Action of UV Light. PART III: Genotoxicology. 11. An Assessment of the Risk of Chemical Mutagens.

Erscheinungsdatum	05.12.2019
Zusatzinfo	207 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	156 x 234 mm
Gewicht	521 g
Themenwelt	Geisteswissenschaften ► Sprach- / Literaturwissenschaft ► Anglistik / Amerikanistik
	Geisteswissenschaften ► Sprach- / Literaturwissenschaft ► Literaturwissenschaft
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
ISBN-10	0-367-25515-4 / 0367255154
ISBN-13	978-0-367-25515-2 / 9780367255152
Zustand	Neuware