Eye's Aqueous Humor: From Secretion to Glaucoma (eBook)

Mortimer M. Civan (Herausgeber)

eBook Download: PDF

1997 | 1. Auflage
288 Seiten
Elsevier Science (Verlag)
978-0-08-058516-1 (ISBN)

Infos

This volume presents a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork and canal of Schlemm. It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. In addition, it provides a concise description of the clinical approaches used for assessing these basic transport processes. The book emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from both the clinical and molecular points of view. This phenomenon provides the major indication that aqueous humor secretion is regulated.

Key Features
* Introduces the mechanisms of aqueous humor formation and outflow
* Describes the clinical study of aqueous humor dynamics
* Exposes the research approaches currently applied
* Emphasizes the diurnal rhythm of aqueous humor secretion
* Provides awareness of unanswered questions

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This volume presents a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork and canal of Schlemm. It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. In addition, it provides a concise description of the clinical approaches used for assessing these basic transport processes. The book emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from both the clinical and molecular points of view. This phenomenon provides the major indication that aqueous humor secretion is regulated. - Introduces the mechanisms of aqueous humor formation and outflow- Describes the clinical study of aqueous humor dynamics- Exposes the research approaches currently applied- Emphasizes the diurnal rhythm of aqueous humor secretion- Provides awareness of unanswered questions

Inhalt

Front Cover 1
The Eye's Aqueous Humor From Secretion to Glaucoma 4
Copyright Page 5
Contents 8
Contributors 12
Preface 14
Previous Volumes in Series 16
Chapter 1. Transport Components of Net Secretion of the Aqueous Humor and Their Integrated Regulation 20
I. Introduction 20
II. Structure of Ciliary Epithelium 22
III. Overview of Net Secretion by Ciliary Epithelium 24
IV. Unidirectional Secretion 26
V. Unidirectional Absorption 32
VI. Coordinated Effects on Secretion and Absorption 35
References 37
Chapter 2. Molecular Approaches to the Study of the Na+,K+-ATPase and Chloride Channels in the Ocular Ciliary Epithelium 44
I. Introduction 44
II. Na+,K+-ATPase 47
III. Regulation of Na+,K+-ATPase 56
IV. Molecular Characterization of the Chloride Channel CIC-3 and the Chloride Channel Regulator, PICln in the Ocular Ciliary Epithelium 58
V. Additional Transporter Genes Identified in the Ocular Ciliary Epithelium 67
References 67
Chapter 3. Chloride Channels in the Ciliary Epithelium 74
I. Introduction 74
II. Volume-Activated Chloride Channels 76
III. Agonist- Activated Chloride Channels 80
IV. Anion-Selective Channels 80
V. Nonselective Channels 82
VI. Role of Chloride Channels 82
References 85
Chapter 4. Identification of Potassium Channels in Human Lens Epithelium 88
I. Introduction 88
II. Electrophysiological Characterization 90
III. Molecular Biological Characterization 99
IV. Summary 119
References 120
Chapter 5. Aquaporin Water Channels in Eye and Other Tissues 124
I. Introduction 124
II. Discovery of the Aquaporins 125
III. Molecular Structure 127
IV. Genetic Origins of the Aquaporins 129
V. Distribution and Physiology 132
VI. Summary 144
References 144
Chapter 6. Gap Junctions and Interlayer Communication in the Heterocellular Epithelium of the Ciliary Body 156
I. Introduction 156
II. The Gap Junction 158
III. Gap Junctions of the Ciliary Body 162
IV. Functional Studies of Junctional Communication 166
V. Summary 178
References 178
Chapter 7. The Trabecular Meshwork and Aqueous Humor Reabsorption 184
I. Introduction 184
II. Electrophysiology of Cultured Trabecular Meshwork Cells 185
III. Intracellular Calcium 193
IV. Regulation of Intracellular pH 195
V. Direct Measurement of Contractility of Isolated Trabccular Meshwork and Ciliary Muscle Strips 198
VI. Measurement of Contraction of Cultured Trabecular Meshwork Cells 208
VII. The Perfused Anterior Segment 210
VIII. Summary of Channels, Transporters, and Receptors in the Trabecular Meshwork Cell 212
IX. Functional Synergism/Antagonism Between Trabecular Meshwork and Ciliary Muscle 214
X. Summary 216
References 217
Chapter 8. Circadian Rhythms in Aqueous Humor Formation 224
I. Historical Summary of Investigations 224
II. Methods 230
III. Homologous Desensitization of Circadian Aqueous Flow 234
IV. Do Gap Junctions Participate in the Circadian Rhythm of Aqueous Flow? 243
V. Summary 246
References 248
Chapter 9. Clinical Measurements of Aqueous Dynamics: Implications for Addressing Glaucoma 254
I. Clinical Components of Aqueous Dynamics 255
II. Fluorescein Washout Method of Measuring Aqueous Flow 262
III. Observations Based on Clinical Measurements in Volunteers 270
IV. Observations in Clinical Syndromes 279
V. Effects of Pharmaceutical Agents 287
VI. Noninvasive Measurement of Other Parameters of Aqueous Humor 292
VII. Summary and Future Challenges 297
References 298
Index 306

Produkt-Details

• Erscheint lt. Verlag: 9.2.1997
• Mitarbeit: Herausgeber (Serie): Dale J. Benos, Douglas M. Fambrough, Arnost Kleineller
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Natur / Technik ► Natur / Ökologie
• Themenwelt: Geisteswissenschaften ► Psychologie ► Klinische Psychologie
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Augenheilkunde
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-08-058516-7 / 0080585167
• ISBN-13: 978-0-08-058516-1 / 9780080585161