The Power of Prions (eBook)

The Strange and Essential Proteins That Can Cause Alzheimer’s, Parkinson’s, and Other Diseases

Michel Brahic (Autor)

eBook Download: EPUB

2024
192 Seiten
Princeton University Press (Verlag)
978-0-691-25240-7 (ISBN)

Infos

The remarkable family of proteins that can make us very illbut can also be linked to long-term memory, immunity, and the origin of lifeOver the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson's and Alzheimer'sand this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, andin an extraordinary findingthe part they may have played in the beginnings of life on our planet. In this engaging and accessible book, Michel Brahic tells the story of these amazing and versatile proteins.Brahic, a leading researcher on diseases of the central nervous system, first describes the discovery of prions and their role in infection, beginning with early work on the animal disease scrapie and a mysterious human illness in New Guinea, apparently transmitted by cannibalism. Prions were eventually identified and named by Stanley Prusiner in the 1980s. (Brahic tells us Prusiner's alternate name for prion was ';piaf.') Prion proteins were then revealed as the cause of other illnesses, from ';mad cow' disease and its human counterpart, Creutzfeldt-Jakob disease, to such noninfectious brain disorders as Parkinson's and Alzheimer's. While the prion proteins responsible for diseases are definitively ';bad,' Brahic also explains that these abnormal prions are rare exceptions. Most of the time, prion proteins actually serve ';good' and vital functionsand they may even have been present at the origin of life itself.

Produkt-Details

• Erscheint lt. Verlag: 29.10.2024
• Zusatzinfo: 11 b/w illus.
• Sprache: englisch
• Themenwelt: Geisteswissenschaften ► Psychologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Schlagworte: Abeta • Abeta tau • Acids • Agent • aggregates • aging • alpha • Alzheimer • Alzheimers disease • Amino • Amino Acids • Amyloid • animals • axon • Beta • Bodies • brain • Cells • Chain • Chemical • Copies • Creutzfeldt • dementia • Dendrites • Disease • electric • Environment • experiments • Fibrils • Formation • Function • Gene • Genetic • Human • hypothesis • Immune • Information • Jakob • Kuru • Laboratory • Lesions • lewy • Lewy bodies • Mechanism • Membrane • Memory • mice • Michel Brahic • Microglial • microscope • Molecules • Mouse • mutations • neurons • Neuroscience • Organisms • origin of life • Parkinson • Parkinson’s disease • patients • Plaques • Prion • Prion Proteins • Protein • Protein Folding • proteins • PrP • quality • Research • scientists • Scrapie • seeds • Sheep • Spread • Structure • synapses • Synaptic • Synuclein • Tau • Test • The Power of Prions • The Strange and Essential Proteins That Can Cause Alzheimer’s, Parkinson’s, Other Diseases • Toxic • Viruses • yeast
• ISBN-10: 0-691-25240-8 / 0691252408
• ISBN-13: 978-0-691-25240-7 / 9780691252407