Tumor-Associated Antigens
Wiley-VCH (Verlag)
978-3-527-32084-4 (ISBN)
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Olivier Gires is a group leader at the ENT research department, Munich Medical Center, Germany and leading head of the Clinical Cooperation Group Molecular Oncology at the GSF. In 1999, he obtained his PhD in biology for his work on Epstein-Barr virus´ oncoprotein LMP1. Thereafter, Olivier Gires focused on the identification and molecular characterization of tumor-associated antigens with particular emphasis on the elucidation of the function of the therapeutic target EpCAM. Work by his group unraveled the oncogenic potential of EpCAM along with underlying molecular mechanisms. Additionally, he was decisively involved in the development of the target identification technology AMIDA.
TUMOUR-ASSOCIATED ANTIGENS (TAAS): SUBCLASSES OF TAAS
T cell Antigens in Cancer (A. Paschen)
Human Tumour Antigens, Immunosurveillance, and Cancer Vaccines (O.J. Finn)
METHODS TO DETECT TAAS
Humoral Antigens in Cancer: Serological Identification Methods, Part I: SEREX (M. Pfreundschuh)
Humoral Antigens in Cancer: Serological Identification Methods, Part II: Proteomex and AMIDA (B. Seliger, O. Gires)
cDNA and Microarray-Based Technologies (F. Marincola, Ena Wang)
Detection and Identification of TAA by SELDI-TOF (F. von Eggeling, C. Melle)
TAAS AND THEIR USEFULNESS
Minor Histocompatibility Antigens and TAAs for Pediatric Cancers (U. Behrends, J. Mautner)
TAAs and their Regulation/Epigenetics (M. Maio)
Cancer-Testis Antigens (CT-antigens) (J.S. Cebon)
Animal Models for TAAs (P. McLaughlin)
Epithelial Cell Adhesion Molecule EpCAM in cancer (CD326) (P.A Baeuerle, G. Riethmüller)
Carcinoembryonic Antigen CEA (W. Zimmermann, R. Kammerer)
Her2/neu and Herceptin (B. Seliger)
Epstein-Barr Virus (EBV) Tumour-Associated Antigens (C. Mancao, W. Hammerschmidt)
Human Papilloma Virus (HPV) Tumour-Associated Antigens (A. Kaufmann)
Circulating TAAs: Biomarkers for Ovarian Cancer Diagnosis (E. Seregni, E. Bombardieri)
CLINICAL APPLICATIONS OF TAAS
Cancer Vaccines (A. Dalgleish)
Peptide Vaccination (D.P. Fairlie)
DNA Vaccination: Human Papilloma Virus (T.C. Wu)
Adoptive T cell transfer (A. Moosmann, A. Krackhardt)
"Overall, the book is very detailed and certainly of use to those working in cancer vaccine and tumour antigen research. It is also readable by those who are not directly in the field but have an interest in cancer and emerging cancer treatments. The general information on techniques provided is also a valuable resource for those considering using these techniques. The book is well produced with few errors." ( Australian Biochemist, August 2010)
| Erscheint lt. Verlag | 26.3.2009 |
|---|---|
| Sprache | englisch |
| Maße | 170 x 240 mm |
| Gewicht | 862 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| Schlagworte | Antigen • Biotechnologie i. d. Biowissenschaften • Biotechnology • Biowissenschaften • Chemie • Chemistry • Life Sciences • Medical oncology • Medical Science • Medizin • medizinische Onkologie • Onkologie • Pharmaceutical & Medicinal Chemistry • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Tumor |
| ISBN-10 | 3-527-32084-9 / 3527320849 |
| ISBN-13 | 978-3-527-32084-4 / 9783527320844 |
| Zustand | Neuware |
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