In Vitro Neuronal Networks

From Culturing Methods to Neuro-Technological Applications

Michela Chiappalone, Valentina Pasquale, Monica Frega (Herausgeber)

Buch | Hardcover

XV, 387 Seiten

2019 | 1st ed. 2019
Springer International Publishing (Verlag)
978-3-030-11134-2 (ISBN)

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This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.

Michela Chiappalone research interests are in the field of Neuroengineering. She obtained a PhD in Electronic Engineering and Computer Science from University of Genova (Italy) in 2003. In 2002 she has been visiting scholar at the Department of Physiology, Northwestern University (Chicago, IL, USA). After a Post Doc at the University of Genova, in 2007 she joined the Neuroscience and Brain Technologies Dept at the Istituto Italiano di Tecnologia (IIT) as a Post Doc. In 2013 she got a group leader position ('Researcher') in the same Institution. In 2015 she has been visiting Professor at KUMED (Kansas City, KS, USA), hosted by Prof. R.J. Nudo. From 2012 to 2015 M. Chiappalone has been Coordinator of the FET Open European Project BrainBow, judged excellent. In 2017, M. Chiappalone joined the Rehab Technologies IIT-INAIL Joint Lab of IIT to lead a group aimed at interfacing robotic devices with the nervous system for applications in neuroprosthetics, neuromodulation and neurorehabilitation. In 2018 she got the national scientific habilitation as Full Professor of Bioengineering. She authored 60 papers published in International Journals, 50 peer-reviewed contributions to International Conferences, 8 Book Chapters and she gave more than 60 scientific talks at International/National Conferences and Research Institutions.

1. Past, present and future of neuronal models in vitro.- 2. In vitro models of neural disorders.- 3. Neuronal cultures and nanomaterials.- 4. Advances in Human Stem Cell Derived Neuronal Cell Culturing and Analysis.- 5. Large scale, high-resolution microelectrode arrays for interrogation of neurons and networks.- 6. Multi-site intracellular recordings.- 7. From MEAs to MOAs: the next generation of bioelectronic interfaces for neuronal cultures.- 8. Scaling spike detection and sorting for next generation electrophysiology.- 9. Burst detection methods.- 10. Reconstruction of functional connectivity from multi-electrode recordings and calcium imaging.- 11. Open-source tools for processing and analysis of in vitro extracellular neuronal signals.- 12. Screening chemicals for potential neurotoxicity and developmental neurotoxicity using neural networks grown on MEAs.- 13. Long-term activity dynamics of single neurons and networks.-14. Electrical and optical closed-loop systems.

Erscheinungsdatum	22.05.2019
Reihe/Serie	Advances in Neurobiology
Zusatzinfo	XV, 387 p. 102 illus., 90 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	763 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	Coating • Micro-Electrode Array • multi-channel acquisition and processing • Neural Interfaces • patterning • Primary cell cultures • stem cell cultures
ISBN-10	3-030-11134-2 / 3030111342
ISBN-13	978-3-030-11134-2 / 9783030111342
Zustand	Neuware