Genomic and Personalized Medicine (eBook)

V1-2

eBook Download: PDF | EPUB

2012 | 2. Auflage
1350 Seiten
Elsevier Science (Verlag)
978-0-12-382228-4 (ISBN)

Infos

Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. - Highly Commended 2013 BMA Medical Book Award for Medicine - More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition - Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics - Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine - Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

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Abbreviations

αDG	Alpha-dystroglycan

α-MSH

α-melanocyte stimulating hormone

β1-AR

β1-adrenergic receptor

μTAS	Micro total analysis system

2D-PAGE

Two-dimensional polyacrylamide gel electrophoresis

3C	Chromatin conformation capture

5C	Chromosome conformation capture carbon copy

6-MMP

6-Methylmercaptopurine

6MP	6-Mercaptopurine

6-MTIMP

6-Methyl-thioinosine-monophosphate

6-TGN

6-Thioguanine nucleosides

6-TIMP

6-Thioinosinemonophosphate

17q21

Chromosome 17q21.31 duplication syndrome

a.a.	Amino acid

AAA	Abdominal aortic aneurysm

AABB	American Association of Blood Banks

AAH	Atypical adenomatous hyperplasia

ABC	Activated B cell

ABC	ATP-binding cassette

ABC DLBCL

Activated B-cell-like diffuse large B-cell lymphoma

ABCB1

ATP-binding cassette, sub-family B, member 1

ABI	Ankle brachial index

Abl	Abelson murine leukemia viral oncogene homolog

ABVD	Adriamycin, bleomycin, vinblastine, and dacarbazine

ACA	Anti-centromere antibodies

ACC	American College of Cardiology

ACCE	Analytical validity, clinical validity, clinical utility, and ethical, legal, and social implications

ACE	Angiotensin-converting enzyme

ACEi	Angiotensin-converting enzyme inhibitors

ACF	Aberrant crypt focus

aCGH	Array comparative genomic hybridization

ACL	Anterior cruciate ligament

ACO	Accountable care organization

ACR	Acute cellular rejection

ACR	American College of Rheumatology

ACS	Acute coronary syndrome

ACT	Artemisinin-based combination therapies

ACTH	Adrenocorticotropic hormone

ACTN1

Alpha actinin

AD	Alzheimer disease

ADAM33

ADAM metallopeptidase domain 33

ADAR-1

RNA-specific adenosine deaminase 1

ADCC	Antibody-dependent cell-mediated cytotoxicity

ADEPT

Antibody-directed enzyme prodrug therapy

ADH	Alcohol dehydrogenase

ADH3	Autosomal dominant hypercholesterolemia

ADHD	Attention deficit hyperactivity disorder

ADI-R

Revised autism diagnostic interview

ADME	Absorption, distribution, metabolism, and excretion

ADOS	Autism diagnostic observation schedule

ADP	Adenosine diphosphate

ADR	Adverse drug reaction

AE	Alternative expression

AED	Antiepileptic drugs

AF	Atrial fibrillation

AFAP	Attenuated FAP

AFib	Atrial fibrillation

AFLP	Amplified fragment length polymorphism

AFP	Alpha-fetoprotein

AGEN-BP

Asian Genetic Epidemiology Network blood pressure

Agr	Accessory gene regulator

AGT	Angiotensin I

AGTR1

Angiotensin receptor 1

AHA	American Heart Association

AHIC	American Health Information Community

AhpC	Alkyl hydroperoxide reductase

AHR	Aryl hydrocarbon receptor

AHRQ	Agency for Healthcare Research and Quality

AI	Allelic imbalance

AIDS	Acquired Immune Deficiency Syndrome

AIH	Autoimmune hepatitis

AIMs	Ancestry informative markers

Akt-v

Akt murine thymoma viral oncogene homolog

AKT	Protein kinase B (PKB)

AKI	Acute kidney injury

ALD	Alcoholic liver disease

ALK	Anaplastic lymphoma kinase

ALL	Acute lymphoblastic leukemia

ALM	Acral lentiginous melanoma

ALOX5

5’-Lipoxygenase

ALPS	Autoimmune lymphoproliferative syndrome

ALS	Amyotrophic lateral sclerosis

ALT	Alanine aminotransferase

AMA	American Medical Association

AMA1	Apical membrane antigen 1

AMCP	Academy of Managed Care Pharmacy

AML	Acute myeloid leukemia

AMP	Association of Molecular Pathologists

AMP	Adenosine monophosphate

AMPK	Adenosine monophosphate-activated protein kinase

AMR	Antibody-mediated rejection

AMT	Accurate mass tags

ANA	Antinuclear antibodies

ANG-1

Angiopoietin 1

ANG-2

Angiopoietin 2

ANKRD1

Ankyrin repeat domain 1

ANN	Artificial neural network

ANP	Atrial natriuretic peptide

APACHE II

Acute Physiology and Chronic Health Evaluation II score

APC	Drotrecogin-α (activated protein C)

APD	Action potential duration

ApiAP2

Apicomplexan AP2 transcription factor

APOC3

Apolipoprotein C3 (gene)

APOE	Apolipoprotein E (gene)

APP	Beta-amyloid precursor protein

AR	Adrenergic receptor

AR	Androgen receptor

ARB	Angiotensin receptor blocker

ARH	Autosomal recessive hypercholesterolemia

ARI	Acute respiratory infections

ARMD	Age-related macular degeneration

ARRA	American Recovery and Reinvestment Act

ARS	Axenfeld–Rieger’s syndrome

ARV	Antiretroviral

ARVC	Arrhythmogenic right ventricular cardiomyopathy

ASCO	American Society of Clinical Oncology

ASCVD

Atherosclerotic vascular disease

ASD	Atrial septal defect

ASD	Autism spectrum disorders

ASO	Antisense oligonucleotide

ASR	Analyte-specific reagent

AT	Angiotensin

ATG16L1

Autophagy-related 16-like 1

ATM	Ataxia telangectasia mutated

ATP	Adenosine...

Produkt-Details

• Erscheint lt. Verlag: 30.10.2012
• Mitarbeit: Chef-Herausgeber: Geoffrey S. Ginsburg, Huntington F Willard
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik
• ISBN-10: 0-12-382228-9 / 0123822289
• ISBN-13: 978-0-12-382228-4 / 9780123822284