Microarray Technology and Cancer Gene Profiling (eBook)
XVIII, 159 Seiten
Springer New York (Verlag)
978-0-387-39978-2 (ISBN)
Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.
Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
Manufacturing of Microarrays 18
Technological Platforms for Microarray Gene Expression Profiling 29
Principles of Gene Microarray Data Analysis 36
Gaining Weights... and Feeling Good about It! 48
Complementary Techniques: 83
Microarrays for Cancer Diagnosis and Classification 91
Gene Profiling for the Prediction of Tumor Response to Treatment: 103
Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs 112
SNP and Mutation Analysis 122
Cancer Development and Progression 134
Gene Expression Profiling in Malignant Lymphomas 151
Tumor Immunology 164
Index 174
| Erscheint lt. Verlag | 28.8.2007 |
|---|---|
| Reihe/Serie | Advances in Experimental Medicine and Biology | Advances in Experimental Medicine and Biology |
| Zusatzinfo | XVIII, 159 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Technik ► Umwelttechnik / Biotechnologie | |
| Schlagworte | classification • DNA • gene expression • genes • Genome • microarray • PCR • SNP • Tumor |
| ISBN-10 | 0-387-39978-X / 038739978X |
| ISBN-13 | 978-0-387-39978-2 / 9780387399782 |
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