Physiology and Toxicology of Male Reproduction (eBook)

Paul M. D. Foster, James C. Lamb (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
282 Seiten
Elsevier Science (Verlag)
978-1-4832-7207-8 (ISBN)

Infos

Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology-by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.

Inhalt

Front Cover 1
Physiology and Toxicology of Male Reproduction 4
Copyright Page 5
Table of Contents 6
Contributors 10
Preface 12
Chapter 1. Introduction 14
Chapter 2. Testicular Organization and Biochemical Function 20
I. Introduction 20
II. Testicular Compartments 21
III. Spermatogenesis 24
IV. The Key Role of the Sertoli Cell 32
V. The Leydig Cell 40
VI. Future Perspectives and Research 43
References 44
Chapter 3. Duct System and Accessory Glands of the Male Reproductive Tract 48
I. Introduction 48
II. Development of Reproductive Tract and Accessory Organs 49
III. Structure and Function of Duct System 53
IV. Structure and Function of Accessory Glands 64
V. Seminal Plasma 73
VI. Conclusions 78
References 79
Chapter 4. Endocrinology and Paracrinology of the Testis 84
I. Introduction 84
II. Endocrine Control of the Testis 85
III. Paracrine Control of the Testis 95
IV. Endocrinology of Puberty 107
V. Endocrinology of Male Infertility 109
VI. Summary arid Future Prospects 111
References 112
Chapter 5. Male Neuroendocrinology and Endocrine Evaluation of Reproductive Disorders 116
I. Introduction 116
II. Brain Control of Reproductive Functions: The Role of Luteinizing Hormone – Releasing Hormone 117
III. Pituitary Factors Regulating Testicular Function 131
IV. Reproductive Dysfunction and Guidelines for Endocrine Exploration of the Infertile Male 140
References 144
Chapter 6. Fundamentals of Male Reproductive Toxicity Testing 150
I. General Approaches to Male Reproductive Toxicity Testing 150
II. Risk Assessment and Male Reproductive Toxicology 163
References 165
Chapter 7. Morphologic Evaluation of Seminiferous Epithelium of the Testis 168
I. Why Morphology? 169
II. Considerations and Methods 171
III. Media Effects and Glycol Methacrylate 176
IV. Examples of Stage-Specific Lesions 180
V. Functional Correlates of Pathology 185
VI. Summary 186
References 187
Chapter 8. Evaluation of Copulatory Behavior and Sperm in Rats: Role in Reproductive Risk Assessment 192
I. Introduction 193
II. Traditional Endpoints in Male Reproductive Risk Assessment 193
III. Expanding the Data Base—Evaluation of Copulatory Behavior 196
IV. Expanding the Data Base—Sperm Evaluations in the Rat 199
V. New Approaches to Improving Quantitative Male Reproductive Risk Assessment 209
References 212
Chapter 9. Genetic Toxicology of Mammalian Male Germ Cells 216
I. Introduction 216
II. Test Methods 221
Bibliography 235
Chapter 10. Application of In Vitro Systems in Male Reproductive Toxicology 238
I. Introduction 238
II. In Vitro Systems from the Male Reproductive Tract 239
III. Methodology for Cell Isolation 241
IV. Application of In Vitro Systems in Toxicity Studies 246
V. Critical Appraisal of the Usefulness of In Vitro Systems 259
VI. Conclusions 265
References 266
Index 270

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-7207-9 / 1483272079
• ISBN-13: 978-1-4832-7207-8 / 9781483272078