Sertoli Cell Biology (eBook)

Michael D. Griswold, Michael K. Skinner (Herausgeber)

eBook Download: PDF

2004 | 1. Auflage
512 Seiten
Elsevier Science (Verlag)
978-0-08-049228-5 (ISBN)

Infos

Sertoli cells assist in the production of sperm in the male reproductive system. This book provides a state-of-the-art update on the topic of sertoli cells and male reproduction. It addresses such highly topical areas as stem cells, genomics, and molecular genetics, as well as provides historical information on the discovery of this type of cell, and the pathophysiology of male infertility.

* Presents the state-of-the-art research on topics such as stem cell research, transplantation and genomics
* Includes contributions from leaders in the field, including several members of the National Academy of Science
* Discusses the pathophysiology of male infertility
* State-of-the-art chapters on current science advancements
* Stands as the only current reference on the topic of sertoli cells

Inhalt

Cover 1
Copyright Page 5
Contents 8
Contributors 12
Preface 16
PART I: INTRODUCTION 18
Chapter 1. History of the Sertoli Cell Discovery 20
Chapter 2. Perspective on the Function of Sertoli Cells 32
Chapter 3. Structure of the Sertoli Cell 36
PART II: SERTOLI CELL DEVELOPMENT 58
Chapter 4. Embryonic Sertoli Cell Differentiation 60
Chapter 5. Sertoli Cell Biology in Fishes and Amphibians 88
Chapter 6. Sertoli Cell Biology in Seasonal Breeders 98
PART III: SERTOLI CELL FUNCTION AND GENE EXPRESSION 110
Chapter 7. Sertoli Cell Gene Expression and Protein Secretion 112
Chapter 8. Sertoli Cell Secreted Regulatory Factors 124
Chapter 9. Proteases and Protease Inhibitors 138
PART IV: SERTOLI CELL ENDOCRINOLOGY AND SIGNAL TRANSDUCTION 170
Chapter 10. FSH Regulation at the Molecular and Cellular Levels: Mechanisms of Action and Functional Effects 172
Chapter 11. In Vivo FSH Actions 188
Chapter 12. Sertoli Cell Endocrinology and Signal Transduction: Androgen Regulation 216
Chapter 13. Thyroid Hormone Regulation of Sertoli Cell Development 234
Chapter 14.The Transforming Growth Factor ß Superfamily in Sertoli Cell Biology 244
PART V: SERTOLI CELL TRANSCRIPTIONAL REGULATION 266
Chapter 15. Transcription Factors in Sertoli Cells 268
Chapter 16. Structure and Regulation of the FSH Receptor Gene 298
PART VI: CELL–CELL INTERACTIONS INVOLVING SERTOLI CELLS 318
Chapter 17. The Role of the Sertoli Cell in Spermatogonial Stem Cell Fate 320
Chapter 18. Sertoli Cell–Somatic Cell Interactions 334
Chapter 19. Sertoli Cell Lines 346
PART VII: SERTOLI CELL PATHOPHYSIOLOGY 360
Chapter 20. Sertoli Cell Toxicants 362
Chapter 21. Conditions Affecting Sertoli Cells 400
PART VIII: SPERMATOGONIAL STEM CELLS 432
Chapter 22. Gonocyte Development and Differentiation 434
Chapter 23. Hormones and Spermatogonial Development 454
Chapter 24. Long-Term Cultures of Mammalian Spermatogonia 466
Chapter 25. Transplantation 488
Index 504

Produkt-Details

• Erscheint lt. Verlag: 23.11.2004
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• ISBN-10: 0-08-049228-2 / 0080492282
• ISBN-13: 978-0-08-049228-5 / 9780080492285