Genetic Toxicology and Cancer Risk Assessment
Marcel Dekker Inc (Verlag)
978-0-8247-4522-6 (ISBN)
- Keine Verlagsinformationen verfügbar
- Artikel merken
This book presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! It comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies - discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. It examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!
Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, "Genetic Toxicology and Cancer Risk Assessment" reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis; calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens; reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models; discusses the threshold concept of carcinogenesis; demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens; considers structural activity relationship (SAR) analysis of chemical carcinogenicity; describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays; illustrates the use of genetic biomarkers for dosimetry analysis and more!
Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, "Genetic Toxicology and Cancer Risk Assessment" is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
Human Cancer GeneticsJason W. Barlow and David MalkinGenetic Toxicity Tests for Predicting CarcinogenicityErrol ZeigerGenotoxic and Nongenotoxic Mechanisms of CarcinogenesisWai Nang ChoyStructure-Activity Relationship (SAR) and its Roles in Cancer Risk AssessmentDavid Y. Lai and Yin-tak WooRegulatory Genetic Toxicology TestsWai Nang ChoyComplementary Genetic Toxicology AssaysB. Bhaskar GollapudiThe Mouse Lymphoma Assay (MLA) Using the Microwell MethodMasamitsu Honma and Toshio SofuniThe In Vitro Micronucleus AssayMarilyn J. Aardema and Micheline Kirsch-VoldersICH Guidelines on Genotoxicity and Carcinogenicity: Scientific Background and Regulatory PracticeLutz Mnller, Peter Kasper, and Leonard SchechtmanNew OECD Genetic Toxicology Guidelines and Interpretation of ResultsMichael C. CiminoDose-Response Relationships in Chemical Carcinogenesis and Cancer Risk AssessmentWerner K. LutzMolecular Epidemiology and BiomarkersJia-Sheng Wang, Jonathan M. Links, John GroopmanQuantitative Cancer Risk Assessment of Nongenotoxic CarcinogensAnna M. Fan and Robert A. HowdRisk Assessment of Genotoxic CarcinogensLauren ZeiseBiologically Based Cancer Risk Assessment ModelsSuresh H. Moolgavkar
| Erscheint lt. Verlag | 31.8.2001 |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| ISBN-10 | 0-8247-4522-1 / 0824745221 |
| ISBN-13 | 978-0-8247-4522-6 / 9780824745226 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
