Immunodominance

The Choice of the Immune System

Buch | Hardcover

XXVI, 288 Seiten

2005 | 1., Aufl.
Wiley-VCH (Verlag)
978-3-527-31274-0 (ISBN)

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This very first handbook on the topic summarizes the current concepts and brings together in one volume the critical arguments concerning the mechanisms relevant to immunodominance. In invited chapters written by the leaders in the field, the mechanisms whereby the immune system chooses the parts of a recognized pathogen in order to start the immune response are explained and the variety of biologic processes are identified that contribute to that choice.
From the contents:
- Mechanics of antigen processing
-Proteosome specificity and immuno-proteosomes
- Effect of the T cell repertoire on dominance
- Effects of pathogens on the immune response

Jeffrey A. Frelinger received his Ph.D. in immunology at the California Institute of Technology, Pasadena in 1973 and worked as a post-doc at the University of Michigan Medical School, Ann Arbor. Since 1988 he is professor and chair at the Department of Microbiology and Immunology and Associate Director for Research at the Center for Infectious Disease at the University of North Carolina, School of Medicine, Chapel Hill, USA. His major research interests are immunogenetics, molecular immunology and cellular immunology.

From the contents:

MECHANICS OF ANTIGEN PROCESSING
Class I (Rock, USA; Neefjes, Netherlands)
Class II (Unanue, USA)
Impact of MHC on epitope selection (Sette, USA)
PROTEOSOME SPECIFICITY AND IMMUNO-PROTEOSOMES
DRIPS (Yewdell, Bennick, USA)
Classical processing (Cresswell, USA)
EFFECT OF THE T CELL REPERTOIRE ON DOMINANCE
Innate repertoire (Rocha, France)
Selected repertoire (Sherman, USA)
Thymic Development (Zuniga, Pflucker, Canada; Robey, USA; Fowlkes, USA)
Regulatory T cells (Paul, USA; O'Garra, UK)
EFFECTS OF PATHOGENS ON THE IMMUNE RESPONSE
Herpes viruses (Rickenson, UK; Moss, Australia; Hill, USA)
HIV (McMichael, UK; Gotch, UK; Tackiguchi; Japan)
Influenza (Doherty, Austalia; Braciale, US)
Listeria (Harty, USA; Pamer, USA)
TB/Leprosy (Flynn, USA; Bloom, USA)
Malaria (Hill, UK; Nussenswieg, USA)
Generation of Memory T cells (Woodland, USA; Heath, Australia)
HTLV (Bangham, UK)
Hepatitis (Chisari, USA)

Sprache	englisch
Maße	170 x 240 mm
Gewicht	730 g
Einbandart	gebunden
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	HC/Biologie/Mikrobiologie • HC/Medizin/Klinische Fächer • Immunologie • Medizinische Chemie • Molekularbiologie • Pharmazeutische Chemie
ISBN-10	3-527-31274-9 / 3527312749
ISBN-13	978-3-527-31274-0 / 9783527312740
Zustand	Neuware