Neurobiology and Clinical Aspects of the Outer Retina
Chapman and Hall (Verlag)
978-0-412-60080-7 (ISBN)
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This comprehensive work reviews the neurobiological organization of the vertebrate outer retina with an emphasis on mammalian systems. An international team of contributors discuss the ways in which outer retinal neurones (photoreceptor, bipolar and horizontal cells) and their interconnections are disrupted in clinical conditions such as Parkinson's disease, paraneoplastic retinopathy, retinitis pigmentosa and other retinal dystrophies. The book begins by reviewing the functional organization and development of the outer retina, then moves on to a discussion of the contributions made by the different retinal neurones and their synaptic circuits to the visual process. Throughout, authors relate basic neurobiology to clinical conditions. Four concluding chapters focus on the mechanisms through which clinical conditions affect the outer retina. The volume should be of interest to all researchers investigating retinal function and dysfunction, general neurobiologists and visual scientists, as well as ophthalmologists and interested clinicians.
Development and morphological organization of photoreceptors. Cell biology and metabolic activity of photoreceptor cells: light-evoked and circadian regulation. Determinants of visual pigment spectral location and photoreceptor cell spectral sensitivity. Molecular biology of visual pigment molecules. Phototransduction, excitation and adaptation. Photoreceptor synaptic output: neurotransmitter release and photoreceptor coupling. Photoreceptor-horizontal cell connectivity: synaptic transmission and remodulation. Horizontal cell coupling and its regulation. Cross-talk between cones and in horizontal cells through the feedback circuit in the vertebrate retina. Neurotransmitter release from horizontal cells. The organization of photoreceptor to bipolar synapses in the outer plexiform layer of the vertebrate retina. Photoreceptor-bipolar cell transmission. Functional architecture of mammalian outer retina and bipolar cells. Neurotransmitter release from bipolar cells. Interplexiform cell connectivity in the outer retina. The involvement of Mueller cells in the outer retina. Clinical aspects: outer retinal dystrophies. Clinical aspect: Retinitis pigmentosa. Clinical aspects: Paraneoplastic retinopathy. Clinical aspects: Parkinson's disease.
| Verlagsort | London |
|---|---|
| Sprache | englisch |
| Maße | 189 x 246 mm |
| Gewicht | 1430 g |
| Einbandart | gebunden |
| Themenwelt | Naturwissenschaften ► Biologie ► Humanbiologie |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 0-412-60080-3 / 0412600803 |
| ISBN-13 | 978-0-412-60080-7 / 9780412600807 |
| Zustand | Neuware |
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