Genes, Development and Cancer

The Life and Work of Edward B. Lewis

Buch | Hardcover

557 Seiten

2004 | 2004 ed.
Springer-Verlag New York Inc.
978-1-4020-7591-9 (ISBN)

Artikel merken

While Edward B. (‘Ed’) Lewis is famous for his contributions to genetics anddev- opmental biology y, few have read his research papers. One reason for this is availability, man ny having been published in obscure journalsor as book chapters. A second is because his papers in those ?elds are very dif?cult to read. The dif?culty derives from the fact that Lewis has published infrequently, thus manypapers are condensed reviews of man nyyears’ work presented largely in summary form rather than in detail. It is not unusual for the reader to have to infer the experimental methods, even the results, from a few sentences. Furthermore, he often presents his results in terms of abstract models; thus it can be dif?cult to separate the data from the models. Ama ajor goal of this book is to make Lewis’ keypapers accessible to researchers and students. The papers are grouped into several sections that re?ect the changing focus of his research. Each section is preceded by commentary designed to place the papers in historical perspective, with respect to Lewis’ own ideas as well as to those of the larger scienti?c community. The commentaries attempt to highlight the key methods and results—as well as the signi?cance—of each paper by explaining the science in terms that should be understandable to upper-level undergraduates, graduate students and professional researchers.

E. B. Lewis and His Science.- Lewis and the Nature of the Gene.- Star-recessive, a spontaneous mutation in Drosophila melanogaster. Proceedings of the Minnesota Academy of Science 7:23–26.- Another case of unequal crossing over in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 27:31–34.- The relation of repeats to position effect in Drosophila melanogaster. Genetics, 30:1377–166.- The pseudoallelism of white and apricot in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 38:953–961.- Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology, 16:159–174.- The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. American Naturalist 88:225–239.- Some aspects of position pseudoallelism. American Naturalist 89:73–89.- Genes and gene complexes. Heritage from Mendel, pp. 17–47.- Lewis and the Genetic Control of Development.- Genes and developmental pathways. American Zoologist, 3:33–56.- A gene complex controlling segmentation in Drosophila. Nature, 276:565–570.- Genetic control of body segment differentiation in Drosophila.- Control of body segment differentiation in Drosophila by the bithorax gene complex.- Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50:155–164.- Lewis and the Molecular Control of Development.- Molecular genetics of the bithorax complex in Drosophila melanogaster. Science, 221:23–29.- The abdominal region of the bithorax complex. Cell, 43:81–96.- Transabdominal, a dominant mutant of the bithorax complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development, 1:111–123.- Molecular basisof Transabdominal—a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 90:1566–1570.- Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 92:8403–8407.- Splits in fruitfuly Hox gene complexes. Nature, 380:116.- Evolution of the homeobox complex in the Diptera. Current Biology, 13:R587–R588.- Lewis and the Somatic Effects of Ionizing Radiation.- Leukemia and ionizing radiation. Science, 125:965&3x2013;972.- Thyroid radiation doses from fallout. Proceedings of the National Academy of Sciences 45:894–897.- Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science, 142:1492–1494.- Ionizing radiation and tumor production. In: Genetic Concepts and Neoplasia, Williams and Wilkins Co, pp. 57–73.- Letters: Leukemia, radiation, and hyperthyroidism. Science, 174:454.- Analysis of lung tumor mortality in the Batelle Beagle Lifespan experiment.- Ionizing radiation, cancer induction and radioactive fallout.- Homeosis: the first 100 years. Trends in Genetics, 10:341–343.- Remembering Sturtevant. Genetics, 141:1227–1230.- C. B. Bridges’ repeat hypothesis and the nature of the gene. Genetics: in press.- Autobiographical sketch.- The bithorax complex: the first fifty years. Les Prix Nobel, 1995. Almquist & Wiksell International: Stockholm, Sweden, pp. 233–260.- Curriculum vitae of E. B. Lewis.- References.

Erscheint lt. Verlag	31.1.2004
Zusatzinfo	XVI, 557 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie
ISBN-10	1-4020-7591-X / 140207591X
ISBN-13	978-1-4020-7591-9 / 9781402075919
Zustand	Neuware