Molecular Toxicology

P. David Josephy (Autor)

Buch | Hardcover

384 Seiten

1996
Oxford University Press Inc (Verlag)
978-0-19-509340-7 (ISBN)

Infos

This work presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. Topics covered include xenobiotic biotransformation, reactive intermediates and interactions with macromolecules, and cloning and analysis of the enzymes of biotransformation.

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This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames, polycyclic aromatic hydrocarbons, and chlorinated compounds.

Inhalt

Introduction; 1. Biochemical Background; 2. Molecular biology and its applications in toxicology; 3. Biological oxidations; 4. Superoxide and superoxide dismutase; 5. Hydrogen peroxide and catalase; 6. The respiratory burst; 7. Lipid Peroxidation; 8. Oxidative stress in the erythrocyte; 9. Introduction to xenobiotic metabolism; 10. Clucuronide formation; 11. Glutathione and detoxication; 12. Arylamine N-Acetyltransferase; 13. Sulfotransferase; 14. Cytochrom P-450; 15. The AH receptor and the toxicity of chlorinated aromatic compounds; 16. Identification of DNA adducts; 17. Chemical mutagenesis; 18. Carcinogenesis: the genetic targets; 19. Polycyclic aromatic hydrocarbon carcinogenesis; 20. Aromatic amines and other N-aryl compounds

Produkt-Details

• Erscheint lt. Verlag: 29.8.1996
• Co-Autor: Bengt Mannervik
• Zusatzinfo: numerous line figures, tables
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• ISBN-10: 0-19-509340-2 / 0195093402
• ISBN-13: 978-0-19-509340-7 / 9780195093407
• Zustand: Neuware