Bioengineering Liver Transplantation

Luc J.W. Van der Laan, Bart Spee, Monique M. A. Verstegen (Herausgeber)

Buch | Softcover

132 Seiten

2019
MDPI (Verlag)
978-3-03921-744-1 (ISBN)

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The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.

Erscheinungsdatum	25.12.2019
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	3D Printing • 3D structuring • Additive Manufacturing • bioengineered organ • copper toxicosis • direct printing • end-stage liver diseases • hepatobiliary stent • Hydrogel • Liver • liver bioreactors • liver regeneration • liver tissue bioengineering • liver transplantation • Medical Device • N/A • oxygen persufflation • Personalized medicine • preclinical large animal model • randomized controlled trail • reconditioning • Regenerative medicine • Stem Cells • stem cell transplantation • Tissue engineering • Wilson disease
ISBN-10	3-03921-744-5 / 3039217445
ISBN-13	978-3-03921-744-1 / 9783039217441
Zustand	Neuware