Solid-Phase Synthesis

A Practical Guide

Buch | Softcover

848 Seiten

2019
CRC Press (Verlag)
978-0-367-39871-2 (ISBN)

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This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Steven A. Kates, Fernando Albericio

The solid support strategy in solid-phase synthesis; amino acids -alpha-amino protecting groups; side-chain protecting groups; solid supports for the synthesis of peptides and small molecules; coupling methods - solid-phase formation of amide and ester bonds; homodetic cyclic peptides; disulfide formation in synthetic peptides and proteins -the state of the art; solid-phase convergent approaches to the synthesis of native peptides and proteins; preparation of glyco-, phospho-, and sulfopeptides; oligonucleotide synthesis; synthesis of oligonucleotide-peptide conjugates and nucleopeptides; the chemistry of peptide nucleic acids; solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics; instrumentation; the purification of synthetic peptides; analysis of synthetic peptides; the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.

Erscheinungsdatum	18.09.2019
Verlagsort	London
Sprache	englisch
Maße	152 x 229 mm
Gewicht	1564 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	0-367-39871-0 / 0367398710
ISBN-13	978-0-367-39871-2 / 9780367398712
Zustand	Neuware