The FOS and JUN Families of Transcription Factors

Peter E. Angel, Peter Herrlich (Autoren)

Buch | Softcover

322 Seiten

2019
CRC Press (Verlag)
978-1-138-56216-5 (ISBN)

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This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

Peter E. Angel, Peter Herrlich

Table of Contents Characteristics of AP-1 Subunits Jun Family, Angel and Herrlich FOS Family, Schuermann Regulation of AP-1 Activity and Synthesis Protein/Protein Interactions: Factors Modulating AP-1 Activity, Sassone-Corsi Steroid Hormone Receptors/AP-1, Cato Post-Translational Modification: Jun Modification, Sachsenmaier and Radler-Pohl FOS Modification, Shaw Nuclear Uptake, Jeanteur Promoter Regulation: C-FOS, Nordheim C-Jun, Mechta and Yaniv Functions in Physiological Processe AP-1 Regulated Target Genes, Busslinger Neural Cell Function, Sassone-Corsi Differentiation, Rather Stress Response, Rahmsdorf Functions in Pathology FOS and Jun Oncogenes: FOS in Transformation, Miller Jun in Transformation, Vogt Oncogenes Acting through FOS and Jun: Raf Kinase, Rapp Other Oncogenes, Schanthal Adenovirus E1A/AP-1 Connection, van Dam and van der Eb Tumor Promotion and Carcinogenesis, Yuspa Tumor Progression, Hart

Erscheinungsdatum	18.01.2019
Reihe/Serie	CRC Press Revivals
Verlagsort	London
Sprache	englisch
Maße	150 x 222 mm
Gewicht	594 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-138-56216-5 / 1138562165
ISBN-13	978-1-138-56216-5 / 9781138562165
Zustand	Neuware