Metals in the Brain

Measurement and Imaging

Buch | Softcover

270 Seiten

2018 | Softcover reprint of the original 1st ed. 2017
Humana Press Inc. (Verlag)
978-1-4939-8338-4 (ISBN)

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This volume explores methods used to examine metal levels and distribution in brain tissue or brain-derived cells. The chapters in this book discuss the use of fluorescent metal probes, synchrotron-based X-ray microscopy, ICP-MS, laser ablation-ICP-MS, laser-based tissue microdissection, MRI image analysis, fractionation of cell tissue samples for metal analysis, and metal treatment of cells. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.

Practical and cutting-edge, Metals in the Brain: Measurement and Imaging is a valuable resource for researchers in the rapidly growing area of neuroscience research.

Introduction and Overview.- X-Ray Microscopy for Detection of Metals in the Brain.- Imaging Metals in the Brain by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.- Fluorescent Probes for the Analysis of Labile Metals in the Brain Cells.- Probing Biological Trace Metals with Fluorescent Indicators.- Microdissection of Brain Tissue to Resolve the Comparative Dissemination of Metal Concentrations in Neurodegenerative Diseases, Focusing on Manganese.- Analysis of Trace Elements and Metalloproteins in Fractionated Human Brain Samples using Size Exclusion Inductively Couples Mass Spectrometry.- Size-Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer’s Disease.- Lead Uptake and Localization in Glial Cell Cultures.- Evaluating Iron Flux in the Brain.- Current Methods used to Probe and Quantify Intracellular Total and Free Zn(II) Dynamics, and Subcellular Distribution in Cultured Neurons.- Monitoring Intracellular Zn2+ using Fluorescent Sensors: Facts and Artifacts.- Measuring Changes in Brain Manganese or Iron using Magnetic Resonance Imaging (MRI).- Treatment and Measurement of Metals in Brain Cell Cultures.

Erscheinungsdatum	18.08.2018
Reihe/Serie	Neuromethods ; 124
Zusatzinfo	31 Illustrations, color; 27 Illustrations, black and white; XII, 270 p. 58 illus., 31 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	fixation artifacts • high resolution metal imaging • metal-probes • Microscopy • Trace elements
ISBN-10	1-4939-8338-5 / 1493983385
ISBN-13	978-1-4939-8338-4 / 9781493983384
Zustand	Neuware