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Kidney Development and Disease -

Kidney Development and Disease

Rachel K. Miller (Herausgeber)

Buch | Softcover
XI, 372 Seiten
2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-84650-7 (ISBN)
CHF 299,55 inkl. MwSt
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Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes.


Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadenedour understanding of nephron development and maintenance as well as the diseases related to these processes.  

Part A Model Systems of Kidney Development and Disease.- 1 Drosophila Malpighian tubule: A model for understanding kidney development, function and disease.- 2 Zebrafish pronephros development.- 3 Zebrafish as a model of kidney disease.- 4 Use of Xenopus frogs to study renal development/repair.- Part B Cell Renewal, Differentiation and Fate in Nephrogenesis.- 5 Tissue-specific p53 functions during kidney development.- 6 Growth factor regulation in the nephrogenic zone of the developing kidney.- 7 Development and diseases of the collecting ductsystem.- 8 Origin and function of the renal stroma in health and disease.- Part C Nephron Morphogenesis and Maintenance.- 9 Imaging, analysing and interpreting branching morphogenesis in the developing kidney.- 10 Genetic syndromes affecting kidney development.- 11 Primary cilia in cystic kidney disease.- 12 Inflammation and fibrosis in polycystic kidney disease.- 13 Epithelial to mesenchymal transition (EMT) andendothelial to mesenchymal transition (EndMT): Role and implications in kidney fibrosis.

Erscheinungsdatum
Reihe/Serie Results and Problems in Cell Differentiation
Zusatzinfo XI, 372 p. 51 illus., 50 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 5796 g
Themenwelt Naturwissenschaften Biologie Genetik / Molekularbiologie
Schlagworte cell differentiation • Cell renewal • Kidney development • Kidney Disease • Morphogenesis • Nephrology
ISBN-10 3-319-84650-7 / 3319846507
ISBN-13 978-3-319-84650-7 / 9783319846507
Zustand Neuware
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