Chemically-Induced DNA Damage, Mutagenesis, and Cancer

Buch | Softcover

X, 264 Seiten

2018
MDPI (Verlag)
978-3-03897-129-0 (ISBN)

Titel nicht im Sortiment

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Human cancers frequently arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. However, the replication of damaged DNA may occur frequently prior to repair, resulting in gene mutations and the generation of altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle give rise to a clonal cell population with an advantage in proliferation. The complex process of carcinogenesis includes many such events, but has been generally considered to be comprised of the three main stages known as initiation, promotion, and progression, which ultimately give rise to the induction of human cancer. The articles published in this book entitled “Chemically-Induced DNA Damage, Mutagenesis, and Cancer” provide an overview on the topic of the “consequence of DNA damage” in the context of human cancer with their challenges and highlights.

Erscheinungsdatum	11.08.2018
Mitarbeit	Gast Herausgeber: Ashis K. Basu, Takehiko Nohmi
Verlagsort	Basel
Sprache	englisch
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Schlagworte	Apoptosis • chemoprevention • Chemotherapy • DNA Damage • DNA repair • genotoxicity • melanoma • Metal toxicity • translesion synthesis • Tumor cells
ISBN-10	3-03897-129-4 / 3038971294
ISBN-13	978-3-03897-129-0 / 9783038971290
Zustand	Neuware