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Endocytosis and Signaling -

Endocytosis and Signaling

Christophe Lamaze, Ian Prior (Herausgeber)

Buch | Hardcover
VIII, 329 Seiten
2018 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-96703-5 (ISBN)
CHF 239,65 inkl. MwSt
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This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks' output. 

In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms' development.  


Preface.- The endosomal network: mediators and regulators of endosome maturation.- Integration of the endocytic system into the network of cellular functions.- GTPases Rac1 and Ras signaling from endosomes.- ESCRT and membrane protein ubiquitination.- Retromer and it's role in regulating signaling at endosomes.- The lysosome and intracellular signaling.- Interplay of endocytosis and growth factor receptor signaling.- Role of the endocytosis of caveolae in intracellular signaling and metabolism.- EGFR trafficking in physiology and cancer.- Evolving view of membrane trafficking and signaling systems for G protein-coupled receptors.- Endosomal trafficking during mitosis and Notch-dependent asymmetric division.

Erscheinungsdatum
Reihe/Serie Progress in Molecular and Subcellular Biology
Zusatzinfo VIII, 329 p. 28 illus., 27 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 815 g
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Biologie Zellbiologie
Schlagworte Caveolae • Cell Cycle Analysis • cell signaling • endocytic trafficking • endocytosis • endosome • lysosomes • transmembrane receptor • vesicle
ISBN-10 3-319-96703-7 / 3319967037
ISBN-13 978-3-319-96703-5 / 9783319967035
Zustand Neuware
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