A Metaheuristic Approach to Protein Structure Prediction

Algorithms and Insights from Fitness Landscape Analysis

Nanda Dulal Jana, Swagatam Das, Jaya Sil (Autoren)

Buch | Hardcover

XXIX, 220 Seiten

2018 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-74774-3 (ISBN)

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This book introduces characteristic features of the protein structure prediction (PSP) problem. It focuses on systematic selection and improvement of the most appropriate metaheuristic algorithm to solve the problem based on a fitness landscape analysis, rather than on the nature of the problem, which was the focus of methodologies in the past.

Protein structure prediction is concerned with the question of how to determine the three-dimensional structure of a protein from its primary sequence. Recently a number of successful metaheuristic algorithms have been developed to determine the native structure, which plays an important role in medicine, drug design, and disease prediction.

This interdisciplinary book consolidates the concepts most relevant to protein structure prediction (PSP) through global non-convex optimization. It is intended for graduate students from fields such as computer science, engineering, bioinformatics and as a reference for researchers and practitioners.

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Metaheuristic Protein Structure Prediction-An Overview.- Related Works.- Continuous Landscape Analysis using Random Walk Algorithm.- Landscape Characterization and Algorithms Selection for the PSP Problem.- The Levy distributed Parameter Adaptive Metaheuristic Algorithm for Protein Structure Prediction.- Protein Structure Prediction using Improved Variants of Metaheuristic Algorithms.- Hybrid Metaheuristic Approach for Protein Structure Prediction.- Conclusions and Future Research.

Erscheinungsdatum	29.03.2018
Reihe/Serie	Emergence, Complexity and Computation
Zusatzinfo	XXIX, 220 p. 59 illus., 54 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	532 g
Themenwelt	Informatik ► Theorie / Studium ► Künstliche Intelligenz / Robotik
	Naturwissenschaften ► Biologie ► Biochemie
	Technik
Schlagworte	AB off-lattice Model • Complexity • Fitness Landscape Analysis • Metaheuristic Algorithms • Protein Structure • Protein Structure Prediction • PSP
ISBN-10	3-319-74774-6 / 3319747746
ISBN-13	978-3-319-74774-3 / 9783319747743
Zustand	Neuware