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Progress in Hormone Biochemistry and Pharmacology

Michael Briggs, Alan Corbin (Autoren)

Buch | Hardcover

312 Seiten

1980
Kluwer Academic Publishers (Verlag)
978-0-85200-547-7 (ISBN)

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Somatostatin was discovered in 1971, by Guillemin and his colleagues during their search for the hypothalamic growth hormone-releasing factor. A peptide was found in ovine hypothalamus which inhibited the release of growth hormone from cultured anterior pituitary cells. 1,2 Determination 3 of its amino acid sequence indicated that it was a tetradecapeptide with a molecular weight of 1639 (Figure lJ. An identical peptide was later isolated from porcine hypothalamus by Schally and his coworkers. 4 The peptide was named somatostatin in the belief that it was a hypothalamic releasing factor whose sole function was to inhibit the secretion of growth hormone. It soon became evident, however, that a peptide with identical immunologic characteristics and biologic activity was present in the D cells of pancreatic islets, in D-like cells of the gastrointestinal tract, in parafollicular cells of the thyroid gland, and in extrahypo- thalamic neurons of both the central and peripheral nervous system in various species, including man.
Moreover, studies employing synthetic somatostatin5 demonstrated that the peptide possessed a wide spectrum of biologic activities in addition to its inhibition of growth hormone. 56 S 0 MAT 0 S TAT I N 6 1 2 3 4 5 7 Ala-Gly-Cys-Lys-Asn-Phe-Phe I I S Trp 8 ~ L~S 9 I I Cys-Ser-Thr-Phe-Thr 14 13 12 11 10 FIG. 1: Structure of somatostatin 57 II. GENERAL DISTRIBUTION AND ACTIONS Somatostatin is widely distributed within both the central and peripheral nervous systems and in various other tissues (Table 1).

1 The Renin-Angiotensin System, Converting Enzyme Inhibition, and Antihypertensive Therapy.- The Renin-Angiotensin-Aldosterone System and the Kallikrein-Kinin-Prostaglandin System.- Converting Enzyme Inhibition: Biochemical and Pharmacological Studies.- Effects on Blood Pressure.- Antihypertensive Actions in Man.- Hemodynamics.- Endocrinological Effects.- Water, Sodium, and Potassium.- Congestive Heart Failure.- Hemorrhagic Shock.- Mechanism of Action.- References.- 2 The Pharmacology and Potential Clinical Applications of Somatostatin and its Analogues.- Background.- General Distributions and Actions.- Mechanism of Action.- Metabolism.- Physiologic Role of Endogenous Somatostatin.- Regulation of Pancreatic Somatostatin Secretion in Vitro.- Therapeutic Potential of Somatostatin in Diabetes Mellitus and other Disorders.- Structure-Activity Relationships: Analogues.- References.- 3 Botanical Sources of Fertility Regulating Agents: Chemistry and Pharmacology.- Estrogenic Plants.- Fertility Control in the Female.- Vaginal Contraceptives.- Fertility Control in the Male.- Discussion.- References.- 4 Luteinizing Hormone Releasing Hormone and Analogues: Conceptive and Contraceptive Potential.- Conceptive Aspects.- Contraceptive Aspects.- Conclusions.- References.

Erscheint lt. Verlag	3.11.1980
Reihe/Serie	Progress in Hormone Biochemistry ; 1
Zusatzinfo	8 black & white illustrations, biography
Verlagsort	Dordrecht
Sprache	englisch
Maße	160 x 250 mm
Gewicht	450 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-85200-547-4 / 0852005474
ISBN-13	978-0-85200-547-7 / 9780852005477
Zustand	Neuware