Computational Methods for Three-Dimensional Microscopy Reconstruction

Gabor T. Herman, Joachim Frank (Herausgeber)

Buch | Softcover

260 Seiten

2016 | Softcover reprint of the original 1st ed. 2014
Birkhauser Boston Inc (Verlag)
978-1-4939-4691-4 (ISBN)

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Approaches to the recovery of three-dimensional information on a biological object, which are often formulated or implemented initially in an intuitive way, are concisely described here based on physical models of the object and the image-formation process. Both three-dimensional electron microscopy and X-ray tomography can be captured in the same mathematical framework, leading to closely-related computational approaches, but the methodologies differ in detail and hence pose different challenges. The editors of this volume, Gabor T. Herman and Joachim Frank, are experts in the respective methodologies and present research at the forefront of biological imaging and structural biology.

Computational Methods for Three-Dimensional Microscopy Reconstruction will serve as a useful resource for scholars interested in the development of computational methods for structural biology and cell biology, particularly in the area of 3D imaging and modeling.

1 Introduction.- 2 Interchanging geometry conventions in 3DEM: Mathematical context for the development of standards.- 3 Fully automated particle selection and verification in single-particle cryo-EM.- 4 Quantitative analysis in iterative classification schemes for cryo-EM applications.- 5 High-resolution cryo-EM structure of the Trypanosoma brucei ribosome of a case study.- 6 Computational methods for electron tomography of influenza virus.- 7 Reconstruction from microscopic projections with defocus-gradient and attenuation effects.- 8 Soft X-ray tomography imaging for biological samples.- 9 Using component trees to explore biological structures.

Erscheinungsdatum	11.09.2016
Reihe/Serie	Applied and Numerical Harmonic Analysis
Zusatzinfo	59 Illustrations, color; 52 Illustrations, black and white; XIII, 260 p. 111 illus., 59 illus. in color.
Verlagsort	Secaucus
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Mathematik / Informatik ► Mathematik ► Angewandte Mathematik
	Mathematik / Informatik ► Mathematik ► Geometrie / Topologie
	Mathematik / Informatik ► Mathematik ► Graphentheorie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	classification • computational methods • Inverse Problems • structural biology • three-dimensional microscopy reconstruction
ISBN-10	1-4939-4691-9 / 1493946919
ISBN-13	978-1-4939-4691-4 / 9781493946914
Zustand	Neuware