Molecular and Cellular Biology of Diabetes Mellitus
John Wiley & Sons Inc (Verlag)
978-0-471-50392-7 (ISBN)
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The second of this three-part series shifts to the molecular biology of insulin action at the level of the cell in both normal and abnormal states. The book begins with the evolution of the insulin molecule and its receptor. Several chapters discuss the structure and function of the insulin receptor and its cellular itinerary, with particular emphasis on the importance of the insulin receptor kinase and receptor gene structure-function relationships. The book further explores these mechanisms as they relate to the cellular and molecular pathogenesis of insulin resistance, and also fully describes the trans-membrane signal for insulin action.
Partial table of contents:; Evolution of Insulin and the Insulin Receptor (D. LeRoith, et al.); Molecular and Cellular Biology of the Insulin Receptor in Diabetes Mellitus (I. Goldfine & J. Caro); Phosphorylation, the Insulin Receptor, and Insulin Action (S. Shoelson & C. Kahn); The Intracellular Itinerary of Insulin Receptors (S. Marshall); In vitro Mutagenesis and the Analysis of Insulin Receptor Function (D. McClain & J. Olefsky); The Insulin Receptor Kinase: Structure-Function Relationships (J. Avruch); Cellular and Molecular Pathogenesis of Insulin Resistance (W. Garvey); Molecular Mechanisms of Insulin Resistance (S. Taylor); Transmembrane Signaling in Insulin Action (A. Saltiel); Glycerolipid Mediators of Insulin Action (R. Pollet); Insulin Regulation of Protein Synthesis (L. Jefferson & S. Kimball); Regulation of Insulin by Cellular Growth and Proliferation: Relation to the Insulin-Like Growth Factors (D. Straus); Use of Fusion Genes to Analyze the Effect of Insulin on PEPCK Gene Transcription (M. Magnuson & D. Granner); Insulin Regulation of Growth Hormone Gene Expression (D. Prager & S. Melmed); Insulin Action and the Glucose Transporter Gene (J. Flier & P. Matsouka); Genetic Control of the Immune Response to Insulin (M. Atkinson & N. Maclaren); Calcium and Insulin Action (D. Sacks & J. McDonald); Insulin Action in the Fetal-Placental Unit (M. Sperling & S. Devaskar); Index.
| Erscheint lt. Verlag | 17.5.1989 |
|---|---|
| Reihe/Serie | Molecular & cellular biology of diabetes mellitus ; Vol 2 |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 61 x 81 mm |
| Gewicht | 822 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Diabetologie |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 0-471-50392-4 / 0471503924 |
| ISBN-13 | 978-0-471-50392-7 / 9780471503927 |
| Zustand | Neuware |
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