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Absolute Risk - Ruth M. Pfeiffer, Mitchell H. Gail

Absolute Risk

Methods and Applications in Clinical Management and Public Health
Buch | Hardcover
226 Seiten
2017
Crc Press Inc (Verlag)
978-1-4665-6165-6 (ISBN)
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This book addresses the development, evaluation, and application of models of absolute risk- the probability of developing a specific disease over a specified time interval in the presence of competing causes of mortality. It discusses the development of appropriate statistical methods for estimating and applying absolute risk.
Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:






Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression



Discusses various sampling designs for estimating absolute risk and criteria to evaluate models



Provides details on statistical inference for the various sampling designs



Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications



Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies



Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis. Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association. Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

Introduction. Definitions and Basic Concepts for Survival Data in a Cohort without Covariates. Developing Absolute Risk Models from Cohort Data with Covariates. Estimating Absolute Risk from Case-Cohort and Nested Case-Control Data. Estimating Absolute Risk from Population-Based Case-Control and Registry Data. Evaluation of Adequacy of Model. Comparing Two Models. Special Topic: Disease Prognosis. Special Topic: Family-Based Designs

Erscheint lt. Verlag 1.10.2017
Reihe/Serie Chapman & Hall/CRC Monographs on Statistics and Applied Probability
Zusatzinfo 50 Illustrations, black and white
Verlagsort Bosa Roca
Sprache englisch
Maße 178 x 254 mm
Gewicht 589 g
Themenwelt Mathematik / Informatik Mathematik
Studium Querschnittsbereiche Epidemiologie / Med. Biometrie
Naturwissenschaften Geowissenschaften Geophysik
ISBN-10 1-4665-6165-3 / 1466561653
ISBN-13 978-1-4665-6165-6 / 9781466561656
Zustand Neuware
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