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Mathematical Modeling and Scale-Up of Liquid Chromatography

With Application Examples

Tingyue Gu (Autor)

Buch | Hardcover

XV, 207 Seiten

2015 | 2nd ed. 2015
Springer International Publishing (Verlag)
978-3-319-16144-0 (ISBN)

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Tingyue Gu's second edition provides a comprehensive set of nonlinear multicomponent liquid chromatography (LC) models for various forms of LC, such as adsorption, size exclusion, ion-exchange, reversed-phase, affinity, isocratic/gradient elution and axial/radial flow LC. Much has advanced since the first edition of this book and the author's software, described here, is now used for teaching and research in 32 different countries. This book comes together with a complete software package with graphical user interface for personal computers, offered free for academic applications. Additionally, this book provides detailed methods for parameter estimation of mass transfer coefficients, bed voidage, particle porosity and isotherms. The author gives examples of how to use the software for predicitons and scale-up. In contrast to the first edition, authors do not need to deal with complicated math. Instead, they focus on how to obtain a few parameters for simulation and how to compare simulation results with experimental data. After reading the detailed descriptions in the book, a reader is able to use the simulation software to investigate chromatographic behavior without doing actual experiments. This book is aimed at readers who are interested in learning about LC behaviors and at those who want to scale up LC for preparative- and large-scale applications. Both academic personnel and industrial practitioners can benefit from the use of the book. This new edition includes:
- New models and software for pellicular (cored) beads in liquid chromatography
- Introduction of user-friendly software (with graphical user interface)
- Detailed descriptions on how to use the software
- Step-by-step instructions on parameter estimation for the models
- New mass-transfer correlations for parameter estimation
- Experimental methods for parameter estimation
- Several actual examples using the model for product development and scale-up
- Updated literaturereview

Dr. Tingyue Gu is a professor in the Department of Chemical & Biomolecular Engineering at Ohio University. He obtained his PhD degree in chemical engineering from Purdue University in 1990. His PhD work was devoted to liquid chromatography (LC) theories and modeling. Dr. Gu has solved a series of LC models numerically for various forms of LC and developed a comprehensive software package with graphical user interface. His software has been used in over 34 countries by numerous people. The software is offered for free for academic applications. It has also been commercially licensed by major companies including leading biotech and pharmaceutical companies. The software has been successfully used for product development with huge savings in time through simulation. Apart from LC, his current research also encompasses bioenergy, biofilm electrochemistry, biocorrosion, and microbial fuel cells.

Introduction.- Literature Review.- General Multicomponent Rate Models for Column Liquid Chromatography.- Parameter Estimation.- Mass Transfer Effects in Liquid Chromatography Simulation.- Interference Effects in Multicomponent Chromatography.- System Peaks in Multicomponent Elution.- Modeling and Scale-up of Size Exclusion Chromatography.- Modeling of LC with cored beads.- Modeling of Slow Kinetics and Affinity Chromatography.- Multicomponent Adsorption with Uneven Saturation Capacities.- Modeling of Multicomponent Gradient Elution.- Modeling of Ion-Exchange Chromatography.- Multicomponents Radial Flow Chromatography.

"This book is a welcome addition for those who want to better understand the modeling of nonlinear liquid chromatography. ... The combination of this book with the Chromulator software makes this a good teaching resource for specialized undergraduate or graduate chemistry as well as chemical engineering courses. ... This book is definitely written in the language of chemical engineers, but chemists and other users of chromatography will also appreciate its capacity to improve their understanding of the modeling of chromatography." (Attila Felinger, Analytical and Bioanalytical Chemistry, April, 2016)

Erscheint lt. Verlag	14.4.2015
Zusatzinfo	XV, 207 p. 121 illus., 35 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	502 g
Themenwelt	Naturwissenschaften ► Chemie ► Analytische Chemie
Schlagworte	Affinity Chromotography • biochemical engineering • Chromatography • Cored-Bead • Gradient Ellution • Liquid chromatography • Mass Transfer Effects • Multicomponent Rate Models • Parameter Estimation • Parameter Sensitivity • Radial Flow Chromatography • Steric Mass-Action Isotherm
ISBN-10	3-319-16144-X / 331916144X
ISBN-13	978-3-319-16144-0 / 9783319161440
Zustand	Neuware