MicroRNAs: Key Regulators of Oncogenesis (eBook)

Sadegh Babashah (Herausgeber)

eBook Download: PDF

2014 | 2014
XXVI, 433 Seiten
Springer International Publishing (Verlag)
978-3-319-03725-7 (ISBN)

Infos

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.

Inhalt

Preface Part I MicroRNAs: biology and implications in cancer1 MicroRNAs and cancer: an overviewSadegh Babashah2 Epigenetics and microRNA in cancerJiazeng Xia, Xiaoqiang Guo, Kaiyuan Deng 3 MicroRNA, diet and cancer chemopreventionSharanjot Saini, Rajvir Dahiya4 MicroRNAs and energy metabolism in cancer cellsLinchong Sun, Xiaoping He, Yang Cao, Ping Gao, Huafeng Zhang5 MicroRNAs and solid tumorsGianpiero Di Leva, Michela Garofalo 6 MicroRNAs and blood cancersCharles H Lawrie 7 MicroRNAs and oncogenic human virusesMuriel Thirion, Teru Kanda, Yoshiki Murakami, Takahiro Ochiya, Hisashi Iizasa8 MicroRNAs linking cancer and inflammation: focus on liver cancerAngélique Gougelet and Sabine Colnot 9 MicroRNAs and regulatory pathways in tumorigenesisJun Wei, Yong Li, Xiaoming Liu, William C. Cho10 MicroRNA-modulated apoptotic and autophagic signaling networks in cancerBo Liu, Yu-quan Wei 11 MicroRNAs and cancer drug resistance and drug sensitivityHugo Seca, Raquel T. Lima, M. Helena Vasconcelos 12 The biological roles of microRNAs in cancer stem cellsBin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Shadan Ali, and Fazlul H. Sarkar Part II MicroRNAs and their clinical implications13 MicroRNAs and clinical implications in cancerJürgen Wittmann 14 MicroRNA expression profiling and its clinical impact in breast cancerManuela Ferracin, Laura Lupini15 MicroRNAs and their clinical impact on resistance to anticancer treatmentKirsten Lindner, Joerg Haier, Richard Hummel 16 Nanocarriers and microRNA-based scenarios for cancer therapyBabak Bakhshinejad, Mohammad Amin Javidi, Sahar Babashah, Sadegh Babashah 17 Challenges and strategies for pulmonary delivery of microRNA-based therapeuticsYu Fujita, Kazuyoshi Kuwano ,Takahiro Ochiya AbbreviationsIndex

Produkt-Details

• Erscheint lt. Verlag: 8.7.2014
• Zusatzinfo: XXVI, 433 p. 26 illus., 21 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: antibacterial drug resistance • Diagnosis • gene expression • MicoRNA • Oncogene • therapy • Tumor suppressor
• ISBN-10: 3-319-03725-0 / 3319037250
• ISBN-13: 978-3-319-03725-7 / 9783319037257