Advances in Metabolic Disorders (eBook)

Volume 2

Rachmiel Levine, Rolf Luft (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
290 Seiten
Elsevier Science (Verlag)
978-1-4831-9498-1 (ISBN)

Infos

Advances in Metabolic Disorders discusses the uric acid and gout, the macroglobulins, the metabolism of testosterone in feminizing testes, tryptophan metabolism, and anabolic steroids. It defines the concept of nitrogen-retaining steroids and their use in disease. The book also explains the meaning of macroglobulinemia. The text examines the genetic factors in the development of gout. The technology involved in the control of purine synthesis is analyzed. The nucleotide degradation and uric acid synthesis are explained. The accumulation of uric acid in gout is discussed in detail. The formation of renal stone is explored. A chapter of the book focuses on a group of antibody molecules. This chapter also introduces cytology, hematology, and serology. A section of the volume is devoted to the source of macroglobulins, chromosomal aberrations, the analysis of urinary metabolites and the nature of macroglobulinemia. The book will provide useful information to doctors, students, and researchers in the field of medicine.

Inhalt

Front Cover 
1 
Advances in Metabolic disorders 
4 
Copyright Page 
5 
Table of Contents 
10 
Contributors 
6 
Preface 
8 
Chapter 1. Gout 
12 
I. Introduction 13
II. Serum Uric Acid Concentration 
13 
III. Purine Biosynthesis 21
IV. Production of Uric Acid in Gout 31
V. Disposition of Uric Acid 42
VI. Renal Function in Gout 45
VII. Pathogenesis of Hyperuricemia in Primary Gout 53
VIII. Acute Gouty Arthritis 58
IX. Pathology of Chronic Gout 64
X. Primary and Secondary Gout 67
XI. 
72 
References 78
Chapter 2. Nitrogen-Retaining Steroids and Their Application in Disease 
90 
I. Introduction 90
II. Pharmacological Evaluation of Nitrogen'Retaining Steroids 
92 
III. Therapeutic Application of Nitrogen-Retaining 
103 
ACKNOWLEDGMENTS 
117 
References 117
Addendum 
123 
Chapter 3. Macroglobulinemia 
126 
I. 
126 
II. Macroglobulinemia: Clinical Picture 130
III. The Macroglobulin 141
IV. Course, Prognosis, and Therapy 153
V. General Discussion 162
References 166
Chapter 4. Testing the Functional Capacity of the Tryptophan-Niacin Pathway in Man by Analysis of Urinary Metabolites 
170 
I. Introduction 171
II. Metabolic Pathway from Tryptophan to Niacin 174
III. Quantitative Methods for Tryptophan Metabolites 177
IV. Ion-Exchange Resins, Columns, and Special Equipment 
204 
V. Factors That Affect the Tryptophan-Niacin Pathway 210
VI. The Loading Dose of Tryptophan 219
VII. Comments on the Conduct of Clinical Studies 223
ACKNOWLEDGMENTS 229
References 230
Chapter 5. 
238 
I. Introduction 238
II. Characteristics of the Syndrome 239
III. Endocrine Studies 251
IV. Comments and Pathogenesis 263
ACKNOWLEDGMENTS 264
References 265
Author Index 
268 
Subject Index 
285 

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• ISBN-10: 1-4831-9498-1 / 1483194981
• ISBN-13: 978-1-4831-9498-1 / 9781483194981