The Eukaryotic Replisome: a Guide to Protein Structure and Function

Buch | Softcover

348 Seiten

2014
Springer (Verlag)
978-94-007-9770-3 (ISBN)

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High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

1. Composition and dynamics of the eukaryotic replisome: a brief overview. - 2. Evolutionary diversification of eukaryotic DNA replication machinery. - 3. The origin recognition complex: a biochemical and structural view. - 4. Archaeal Orc1/Cdc6 Proteins. -5. Cdt1 and Geminin in DNA replication initiation. - 6. MCM structure and mechanics: what we have learned from archaeal MCM. - 7. The Eukaryotic Mcm2-7 Replicative Helicase. - 8. The GINS complex: structure and function. - 9. The Pol α-primase complex. - 10. The structure and function of replication protein A in DNA replication. - 11. Structural biology of replication initiation factor Mcm10. - 12. Structure and function of eukaryotic DNA polymerase d. - 13. DNA polymerase ε. - 14. The RFC clamp loader: structure and function. - 15. PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. - 16. The wonders of Flap Endonucleases: structure, function, mechanism and regulation. - 17. DNA ligase I, the replicative DNA ligase

Erscheint lt. Verlag	21.9.2014
Reihe/Serie	Subcellular Biochemistry ; 62
Zusatzinfo	VIII, 348 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	chromosome replication • DNA Replication • genome duplication • Protein Structure • replisome
ISBN-10	94-007-9770-2 / 9400797702
ISBN-13	978-94-007-9770-3 / 9789400797703
Zustand	Neuware