I Domain Integrins (eBook)
XIV, 179 Seiten
Springer Netherland (Verlag)
978-94-017-9153-3 (ISBN)
The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version.
I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition.
Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book.
In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling.
New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version.I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition.Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book.In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling.New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
Preface1 Evolution of integrin I domainsMark S. Johnson, and Bhanupratap Singh Chouhan2 Integrin a1b1Humphrey Gardner3 Integrin a2b1Asakiran Madamanchi, Samuel A. Santoro, and Mary M. Zutter4 Integrin a10b1- a collagen receptor critical in skeletal developmentEvy Lundgren-Åkerlund and Attila Aszodi5 Integrin a11b1 – a major collagen receptor on fibroblastic cellsCédric Zeltz, Ning Lu, and Donald Gullberg6 Regulation of integrin activity by phosphorylationCarl G. Gahmberg, Mikaela Grönholm, and Liisa M. Uotila7 Integrin aEb7:molecular features and functional significance in the immune systemGregg A. Hadley and Jonathan M.G. Higgins8 Structural aspects of integrinsRobert C. Liddington9 Integrin recognition motifs in the human collagensSamir Hamaia and Richard Farndale10 Cellular signalling by collagen-binding integrinsJyrki Heino11 The therapeutic potential of I-domain integrinsMarian Breenan and Dermot CoxIndex.
| Erscheint lt. Verlag | 14.7.2014 |
|---|---|
| Reihe/Serie | Advances in Experimental Medicine and Biology | Advances in Experimental Medicine and Biology |
| Zusatzinfo | XIV, 179 p. 50 illus., 32 illus. in color. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Technik | |
| Schlagworte | Collagen • I domain • inflammation • Integrin • Leukocytes |
| ISBN-10 | 94-017-9153-8 / 9401791538 |
| ISBN-13 | 978-94-017-9153-3 / 9789401791533 |
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