Interleukin-10 in Health and Disease (eBook)

Simon Fillatreau, Anne O'Garra (Herausgeber)

eBook Download: PDF

2014 | 2014
VIII, 238 Seiten
Springer Berlin (Verlag)
978-3-662-43492-5 (ISBN)

Infos

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Inhalt

IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Karin R. Engelhardt and Bodo GrimbacherControl of intestinal inflammation by interleukin-10.Abhisake Kole and Kevin J. MaloyTr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta and Manuela Battaglia.Interleukin-10-producing B cells and the regulation of immunity.Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa and Simon Fillatreau.Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?Meghan K. Eberhardt and Peter A. BarryIL-10: achieving balance during persistent viral infection.Cherie T. Ng and Michael B.A. OldstoneThe role of microRNAs in the control and mechanism of action of IL-10.Susan R. Quinn, Luke A. O’NeillThe regulation of IL-10 expression.Leona Gabryšová, Ashleigh Howes, Margarida Saraiva and Anne O’GarraThe Molecular Basis of IL-10 Function:  From Receptor Structure to the Onset of Signaling.Mark R. WalterRole of IL-22 in microbial host defenseCeline Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang

Produkt-Details

• Erscheint lt. Verlag: 8.7.2014
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: VIII, 238 p. 16 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Anti-inflammatory cytokine • Counter-regulation of immunity • IL-10 expression • Il-10 polymorphisms • Innate microbial recognition • interleukin-10 • Intestinal immunity • Maintenance of immune homeostasis • TLR triggering • Tr1 cells • Viral IL-10 homologs
• ISBN-10: 3-662-43492-X / 366243492X
• ISBN-13: 978-3-662-43492-5 / 9783662434925