Biochemistry and Biology of Coronaviruses

Buch | Softcover

438 Seiten

2013
Springer-Verlag New York Inc.
978-1-4757-0458-7 (ISBN)

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This book is the result of an international symposium held at the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The intent of this symposium was to provide an opportunity to compare the data on coronavirus structure and replica tion as well as to discuss mechanisms of pathogenesis. For over a decade coronaviruses have been recognized as an important group of viruses which are responsible for a variety of diseases of clinical importance in animals and man. Recently new and interesting data on the molecular biology and pathogenesis of coronaviruses have become available and this led us to organize this meeting. The uniformity and diversity in this virus group was evaluated from a molecular point of view and the replication of coronaviruses appears to involve aspects which may be unique for this virus group. Additionally, in contrast to other positive strand RNA viruses it became clear that coronaviruses readily establish persistent infections in the host, a phenomenon which may lead to the different subacute or chronic disorders manifested during coronavirus infection. This volume presents a series of articles based upon the scientific presentation given at the symposium. In addition, there are two articles by B. W. J. Mahy and D. A. J. Tyrrell which summarize the current state of art concerning the biochemistry and biology of coronaviruses, respective ly. We believe this book will be of interest to all virologists and particularly to both established workers and newcomers to this field. V.

The Structure and Behavior of Coronavirus A59 Glycoproteins.- Structural and Antigenic Relationships between Human, Murine and Avian Coronaviruses.- Antigenic Relationships of Coronaviruses Detectable by Plaque Neutralization, Competitive Enzyme Linked Immunoabsorbent Assay, and Immunoprecipitation.- The RNA and Proteins of Human Coronaviruses.- Genome Structure of Mouse Hepatitis Virus: Comparative Analysis by Oligonucleotide Mapping.- The Structure of the Canine Coronavirus.- Characterisation of Viral RNA in Cells Infected with the Murine Coronavirus JHM.- Relatedness of Virion and Intracellular Proteins of the Murine Coronaviruses JHM and A59.- Assembly of Mouse Hepatitis Virus Strain JHM.- Glycoprotein El of Coronavirus A59: A New Type of Viral Glycoprotein.- Analysis of the Functions of Coronavirus Glycoproteins by Differential Inhibition of Synthesis with Tunicamycin.- Oligonucleotide Fingerprinting of the RNA of Different Strains of Infectious Bronchitis Virus.- Coronavirus Cell-Associated RNA-Dependent RNA Polymerase.- On Enteropathogenic Bovine Coronavirus.- Polypeptide Structure of Bovine Enteritic Coronavirus: Comparison between a Wild Strain Purified from Feces and A HRT 18 Cell Adapted Strain.- The Avian Coronavirus Multiplication Strategy.- Intracellular Protein Synthesis and the in vitro Translation of Coronavirus JHM mRNA.- Messenger RNAs of Mouse Hepatitis Virus A59: Isolation and Characterization, Translation in Xenopus Laevis Oocytes of RNAs 3, 6, and 7, UV Target Sizes of the Transcription Templates.- Murine Coronavirus RNA.- Comparison of the RNAs of Murine and Human Coronaviruses.- Biochemistry of Coronaviruses 1980.- In Vivo and In Vitro Models of Demyelinating Diseases.- Evolution of a Coronavirus. during Persistent Infection In Vitro.- Persistent Infection with Mouse Hepatitis Virus, JHM Strain in DBT Cell Culture.- Characteristics of a Long Term In Vitro Persistent Infection with Human Coronavirus 229 E..- Coronavirus Antibodies in Patients with Multiple Sclerosis.- JHM Infections in Rats as a Model for Acute and Subacute Demyelinating Disease.- Host and Virus Factors Associated with CNS Cellular Tropism Leading to Encephalomyelitis or Demyelination Induced by the JHM Strain of Mouse Hepatitis Virus.- Pathogenicity and Persistence of Mouse Hepatitis in Inbred Strains of Mice.- The Use of a Genetically Incompatible Combination of Host and Virus (MHV) for the Study of Mechanisms of Host Resistance.- Influence of the Immune System on the Course of Infection with Murine Coronavirus JHM in Suckling Mice.- Macrophages and Resistance to JHM Virus CNS Infection.- Vomiting and Wasting Disease, A Coronavirus Infection of Pigs.- Inborn Resistance of Mice to Mouse Hepatitis Virus Type 3 (MHV3): Liver Parenchymal Cells Express Phenotype in Culture.- Biology of Coronaviruses 1980.- Participants.

Reihe/Serie	Advances in Experimental Medicine and Biology ; 142
Zusatzinfo	X, 438 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	1-4757-0458-5 / 1475704585
ISBN-13	978-1-4757-0458-7 / 9781475704587
Zustand	Neuware