Structure, Dynamics, Interactions and Evolution of Biological Macromolecules
Springer (Verlag)
978-94-009-7054-0 (ISBN)
A Colloquium was held in Orleans on July 5-9, 1982, to cele- brate the 80th birthday of Professor Charles SADRON. This meeting was devoted to the "Structure, Dynamics, Interactions and Evolution of Biological Macromolecules", research areas whose development in France owes so much to Pr. Sadron's efforts. The Colloquium was sponsored by the Centre National de la Recherche Scientifique and the Museum National d'Histoire Naturelle. This book is a collection of the plenary lectures delivered during this scientific meeting together with several contributions from former collaborators of Pro Charles Sadron. Charles Sadron was born in 1902 at Chateauroux, near the center of France. After highschool in his native town he moved to the University of Poitiers where he was graduated in Physics and then ob- tained the Agregation degree in 1926. Appointed as a highschool teacher in Strasbourg, he devoted his spare time to research in magnetism under the direction of Pro P. Weiss. He got his Ph. D. from the Uni- versity of Strasbourg in 1932 and then did a post-doctoral work at Caltech with Pr. Von Karman.
Back to France in 1934, he was appoin- ted as Associate Professor at the University of Strasbourg in 1937. His interest in colloidal suspensions and polymers dates back to these ti- mes when he started to study the morphology of chain polymers. When the second world war started, Charles Sadron moved to Clermont-Ferrand with other members of the University of Strasbourg.
I. Nucleic Acids. Structures, Dynamics and Associations with Proteins.- Left-handed DNA in chemical and biological systems.- Theoretical studies of the polymorphism and microheterogeneity of DNA.- Z-DNA and chemical carcinogenesis.- Initiation of carcinogenesis: from the local structural change of DNA to the setting up of a mutation.- Breathing reactions in nucleic acids and proteins.- Conformation of synthetic and natural polyelectrolytes.- DNA conformation and folding: from solution to the higher order structure of chromatin.- Higher orders of chromatin structure.- Structure and dynamics of peptide-nucleic acid complexes.- Molecular mechanisms for the recognition of nucleic acids by proteins. Present-day and prebiotic aspects.- The lac repressor. Structure and interactions.- Role of Messenger RNA specific secondary structure in the control of gene expression.- The organization of plant viral genomes.- Structure, evolution and interactions of ribosomal RNAs.- Liposome-mediated gene transfer in vivo. Uptake and expression of the preproinsulin I gene by rats and mice.- II. Protein Structure and Dynamics.- Theoretical and experimental conformational analysis of some synthetic and natural peptides.- Ligand binding as a probe of protein dynamics.- Dynamics of proteins and of protein assemblies.- Dynamics of proteins.- Conformational fluctuations and enzymatic activity.- X-ray and neutron scattering study of membrane proteins in solution.- Fast kinetic spectroscopies: laser flash photolysis and pulse radiolysis: application to the study of the structure, the dynamics and the interactions of biological molecules.- Fluorescence decay of dansylated yeast 3 phosphoglycerate kinase.- Structure and conformation of carbohydrate chains of N-glycoproteins in model systems.- Wheat germ agglutinin: a review of recent results.- III - Evolution of Biological Macromolecules.- The origin and evolution of life at the molecular level.- Condensation-polymerization and morphogenesis in aqueous medium as a model for the chemical evolution.- Reflections on molecular asymmetry and appearance of life.- Topological and quantitative relationships in evolving genomes.
| Zusatzinfo | 422 p. |
|---|---|
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Maße | 170 x 244 mm |
| Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
| Naturwissenschaften ► Chemie ► Physikalische Chemie | |
| ISBN-10 | 94-009-7054-4 / 9400970544 |
| ISBN-13 | 978-94-009-7054-0 / 9789400970540 |
| Zustand | Neuware |
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