Mechanisms of Atrial Arrhythmias
Insights from the Development of a Biophysically Detailed Model of the Human Atria
Seiten
2013
|
2014
Springer International Publishing (Verlag)
978-3-319-01642-9 (ISBN)
Springer International Publishing (Verlag)
978-3-319-01642-9 (ISBN)
This book describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality.
This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.
This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.
Introduction.- Background.- Development of a new model for simulating the electrical action potentials of human atrial myocytes.- Development of a family of regional cell models.- Autonomic regulation and pathophysiological remodelling.- 3D Anatomical Modelling of the Atria.- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria.- Atrial Fibrillation.- Discussion.
| Erscheint lt. Verlag | 19.11.2013 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XXII, 256 p. 137 illus., 42 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 584 g |
| Themenwelt | Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik |
| Schlagworte | 3D Anatomical Modelling of the Atria • Atrial Fbrillation • Atrial Tchycardia • Autonomic Crdiac Rgulation • Cardiac Mdelling • Electrical Rmodelling • Electrophysiological Mdelling • Pacemaking Mehanisms |
| ISBN-10 | 3-319-01642-3 / 3319016423 |
| ISBN-13 | 978-3-319-01642-9 / 9783319016429 |
| Zustand | Neuware |
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