Gene Therapy for HIV Infection

Buch | Softcover

XVII, 178 Seiten

2013 | 1. Softcover reprint of the original 1st ed. 1998
Springer Berlin (Verlag)
978-3-662-11823-8 (ISBN)

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ince the early 1980s, the HIV epidemic has been raging within the S 1 United States and around the world. Drug therapy for HIV infection has not been curative, prompting the search for alternative strategies to control HIV infection within infected persons. One potential alterna tive to drug therapy is a developing medical technology termed gene therapy. 2 Gene therapy involves introducing genetic elements into popu lations of cells in order to correct or prevent a pathologic process. A large number of gene therapy strategies have been developed in an at tempt to inhibit HIV expression and spread. These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction. In the first strategy, termed genetic immunotherapy by some, genetic material encoding HIV proteins is introduced into patient's cells in order to stimulate a cellular immune response above and beyond 3 5 that stimulated by the viral infection itself. - Two general genetic im munotherapy strategies have been developed. Genes encoding HIV pro teins have been directly injected into the dermis or muscle tissue of patients. These genes have been encoded in plasmids or viral DNA and have been injected either in the form of naked DNA or complexed with lipids.

1. Replicative Cycle of HIV.- 2. Gene Therapy Strategies for Inhibition of HIV.- 3. Trans-Splicing Ribozymes as Potential HIV Gene Inhibitors.- 4. Viral Vectors for HIV Gene Therapy.- 5. T Lymphocyte Based HIV Gene Therapy Strategies.- 6. Stem Cell-Based Gene Therapies in the Treatment of AIDS.- 7. Animal Models of Gene Therapy for AIDS.- 8. Hematopoietic Stem Cell Transplantation and HIV Gene Therapy.

Erscheint lt. Verlag	6.1.2013
Zusatzinfo	XVII, 178 p. 27 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	314 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	AIDS • Diseases • gene therapy • gene transfer • Gentherapie • hematopoietic stem cell • hematopoietic stem cell transplantation • HIV • immune system • Immunsystem • Infection • infectious disease • Infectious Diseases • Infektionskrankheiten • Lymphocytes • Stem Cells • stem cell transplantation • Transplantation • Vektor
ISBN-10	3-662-11823-8 / 3662118238
ISBN-13	978-3-662-11823-8 / 9783662118238
Zustand	Neuware