Apoptosis

Ning Yang, Inge Swie Goping (Autoren)

Buch | Softcover

101 Seiten

2013
Morgan & Claypool Publishers (Verlag)
978-1-61504-538-9 (ISBN)

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Multi-cellular organisms eliminate individual cells through a self-destruct process known as apoptosis. Apoptosis is critical for proper development and maintenance of tissue homeostasis. The importance of this process is highlighted by the fact that too much or too little apoptosis is the underlying cause of pathologies such as cancer, autoimmune diseases (e.g., lupus, arthritis), and neurodegenerative disorders (e.g., Parkinson's, Alzheimer's). In the early days, apoptotic cells were identified strictly by cell morphology. Now we know that biochemical signatures define a number of death programs, of which apoptosis is the most widely understood. In this review, we discuss genetic insights gained from C. elegans, the importance of caspases, engulfment of apoptotic cells, apoptotic signals, the role of mitochondria, the Bcl-2 family, and the link between dysfunctional apoptosis and disease. Within each topic, we highlight landmark studies that contributed to our current understanding of apoptosis. All together, this research exemplifies tremendous scientific synergy between the disciplines of genetics, biochemistry, developmental cell biology, and structural biology. Continued exploration into mechanisms that regulate apoptosis will undoubtedly lead to insights into disease processes with potential therapeutic strategies.

Historical Perspective of Apoptosis
C. elegans and Discovery of the Caspases
Engulfment of Apoptotic Cells: “Find Me” and “Eat Me” Signals
Extrinsic and Intrinsic Apoptotic Signals
The Bcl-2 Family
Apoptosis and Cancer
Summary
References
Author Biographies

Erscheint lt. Verlag	1.8.2013
Reihe/Serie	Colloquium Series on Building Blocks of the Cell: Cell Structure and Function
Verlagsort	San Rafael
Sprache	englisch
Maße	191 x 235 mm
Gewicht	220 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-61504-538-4 / 1615045384
ISBN-13	978-1-61504-538-9 / 9781615045389
Zustand	Neuware