Silicon-mediated Transformations of Functional Groups (eBook)

Helmut Vorbrueggen (Autor)

eBook Download: PDF

2006 | 1. Auflage
XII, 366 Seiten
Wiley-VCH (Verlag)
978-3-527-60592-7 (ISBN)

Infos

In the first work to comprehensively cover this all-important topic, the recognized expert Helmut Vorbrüggen provides both organic and bioorganic chemists with much new and valuable information for preparative synthesis.
Although every organic chemist may be familiar with different aspects of silylation for the protection of functional groups, this book covers the concept of protection while simultaneously silylating-activating various functional groups, such as amides and ureas. This novel methodology opens thus numerous synthetic pathways
while effecting the elimination of water in it volatile persilylated form under rather mild reaction conditions, which are often advantageous compared to conventional methods.
The compact form and clear structure of this monograph make this a long-awaited ready reference.

From the contents:

Introduction
* Techniques of Preparative Silylations-Desilylations
* Preparation and Properties of Siliconoxy-Leaving Groups
* Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide
* Reactions of Aldehydes and Ketones
* Reactions of Alcohols, Ethers and Epoxides
* Reaction of N-O Systems
* Reactions of S-O and Se-O Systems
* Cyclizations and Ring Enlargements
* Base and Acid-Catalyzed as well as Thermal Eliminations of Trimethylsilanol. Peterson Reactions
* Formation of Carbon-Phosphorous Double- and Triple Bonds
* Reductions and Oxidations
* Dehydration-Activation as well as Silylation of Inorganic and Organic Salts and Metalorganic Compounds
* Formation of Polymers Silylgruppen werden vor allem in der Schutzgruppenchemie in vielfältiger Weise eingesetzt. Aber neben dieser wohl bekanntesten Funktion können Silylgruppen auch verschiedenste funktionelle Gruppen in einer Reaktion aktivieren und dem Chemiker bei der Synthese viele Vorteile bringen. Ausserdem lässt sich mit ihrem Einsatz häufig das während der Reaktion entstehende Wasser auf elegante Art eliminieren und somit kann auf drastische Reinigungsbedingungen verzichtet werden.

· erstmalige Zusammenfassung dieses wichtigen Themas
· Helmut Vorbrüggen ist anerkannter Fachmann auf diesem Gebiet
· bietet sowohl Organikern als auch Bioorganikern viele wertvolle Informationen für die präparative Synthese
· kompakte und übersichtliche Gliederung garantiert schnelle Orientierung

Inhalt

Introduction
Techniques of Preparative Silylation and Desilylations
Preparation and Properties of Siliconoxy-Leaving Groups
Reactions of Free and Derivatized Carboxylic Acids and Carbonates
Reactions of Aldehydes and Ketones
Reactions of Alcohols, Ethers and Epoxides
Reactions of N-O Systems
Reactions of S-O and Se-O Systems
Cyclizations and Ring Enlargements
Acid- and Base (Fluoride) Catalyzed Eliminations of Trimethylsilanol and Trimethylsilyl Fluoride
Formation of Carbon-Phosphorous Double- and Triple Bonds
Reductions and Oxidations
Dehydration-Activation as well as Silylation of Metalorganic Compounds and of Inorganic Salts
Formation of Polymers Introduction
Techniques of Preparative Silylation and Desilylations
Preparation and Properties of Siliconoxy-Leaving Groups
Reactions of Free and Derivatized Carboxylic Acids and Carbonates
Reactions of Aldehydes and Ketones
Reactions of Alcohols, Ethers and Epoxides
Reactions of N-O Systems
Reactions of S-O and Se-O Systems
Cyclizations and Ring Enlargements
Acid- and Base (Fluoride) Catalyzed Eliminations of Trimethylsilanol and Trimethylsilyl Fluoride
Formation of Carbon-Phosphorous Double- and Triple Bonds
Reductions and Oxidations
Dehydration-Activation as well as Silylation of Metalorganic Compounds and of Inorganic Salts
Formation of Polymers

Rezensionen

"This handbook is a clear, compact compilation ... an essential practical and reference book for the research chemist." Applied Organometallic Chemistry

"This monograph contains a lot of valuable information and stimulating ideas, which show how the chemist engaged in synthesis can profitably use silyl groups not only as protecting groups but also as activating groups in organic transformations." Angewandte Chemie I.E.

"...very informative and should be of great interest to practicing organic chemists."
Journal of the American Chemical Society

"In summary, this book represents a very valuable reference for the covered fields. It is recommended for every good library collection and will surely find a place on the shelves of the scientists acting in that area." Synthesis

"Das vorliegende Buch vermittelt einen sehr umfassenden, breiten Überblick über unterschiedliche Reagenzien und Reaktionen und ihre Anwendungsgebiete. ... ein sehr gutes Nachschlagewerk, das etliche, alternative Umsetzungen für viele Synthese-Probleme zeigt."
www.organische-chemie.ch

"Für Synthesechemiker birgt das Buch eine Vielzahl an wertvollen Informationen und Anregungen, die aufzeigen, wie Silylgruppen nicht nur als Schutzgruppen, sondern auch als aktivierende Gruppen in organisch-chemischen Transformationen gewinnbringend einzusetzen sind."
Angewandte Chemie

Produkt-Details

• Erscheint lt. Verlag: 6.3.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Schlagworte: Chemie • Chemische Synthese • Chemistry • Coordination Chemistry • Koordinationschemie • Methods - Synthesis & Techniques • Organic Chemistry • Organische Chemie • Organische Chemie / Methoden, Synthesen, Verfahren • Silylgruppen
• ISBN-10: 3-527-60592-4 / 3527605924
• ISBN-13: 978-3-527-60592-7 / 9783527605927