A Structural Perspective on Respiratory Complex I (eBook)

Structure and Function of NADH:ubiquinone oxidoreductase

Leonid Sazanov (Herausgeber)

eBook Download: PDF

2012 | 2012
X, 286 Seiten
Springer Netherland (Verlag)
978-94-007-4138-6 (ISBN)

Infos

The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

Inhalt

Foreword; Leonid SazanovPart I: Structure and mechanism of complex I1. Structure of complex I; Rouslan Efremov and Leonid Sazanov2. On the mechanism of the respiratory complex I; Thorsten Friedrich, Petra Hellwig, and Oliver Einsle3. Iron–sulfur clusters in complex I; Eiko Nakamaru-Ogiso 4. Current Topics of the Inhibitors of Mitochondrial Complex I; Hideto Miyoshi 5. My Fifty Years Association with Complex I Study; Tomoko OhnishiPart II: Evolution of complex I6. The Evolutionary Relationship between Complex I and [NiFe]-hydrogenase; Anne Volbeda and Juan C. Fontecilla-Camps7. Recruitment of the antiporter module - a key event in complex I evolution; Vamsi Krishna Moparthi and Cecilia HägerhällPart III: Mutations in complex I subunits and medical implications8. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach; Takao Yagi, Jesus Torres-Bacete, Prem Kumar Sinha, Norma Castro-Guerrero, and Akemi Matsuno-Yagi 9. Cellular consequences of mtDNA-encoded mutations in NADH:ubiquinone oxidoreductase; Mina Pellegrini, Jan A.M. Smeitink, Peter H.G.M. Willems and Werner J.H. KoopmanPart IV: Subunit composition and assembly of mitochondrial complex I10. The assembly of human complex I; Jessica Nouws, Maria Antonietta Calvaruso, Leo Nijtmans11. Complexes I in the green lineage; Claire Remacle, Patrice Hamel, Véronique Larosa, Nitya Subrahmanian, Pierre CardolPart V: Supercomplexes in mitochondria12. Supramolecular organization of the respiratory chain; Janet Vonck Index

Produkt-Details

• Erscheint lt. Verlag: 11.5.2012
• Zusatzinfo: X, 286 p.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• Schlagworte: Bioenergetics • electron transfer and proton translocation • membrane protein structure • NADH:ubiquinone oxidoreductase (complex I) • Protein Structure • respiratory chain
• ISBN-10: 94-007-4138-3 / 9400741383
• ISBN-13: 978-94-007-4138-6 / 9789400741386