Energy Metabolism and Lifespan Determination (eBook)

M.P. Mattson (Herausgeber)

eBook Download: PDF

2003 | 1. Auflage
226 Seiten
Elsevier Science (Verlag)
978-0-08-049476-0 (ISBN)

Infos

Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production.

During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

Inhalt

Cover 1
Energy Metabolism and Lifespan Determination 2
Copyright Page 5
Table of Content 6
Preface 8
Chapter 1. The Search for Energy: A Driving Force in Evolution and Aging 10
Chapter 2. Insulin Signaling, Glucose Metabolism Oxidative Stress, and Aging 22
Chapter 3. Oxidative Phosphorylation, Mitochondrial Proton Cycling, Free-radical Production and Aging 44
Chapter 4. Protein Turnover, Energy Metabolism, Aging, and Caloric Restriction 78
Chapter 5. Cellular and Molecular Mechanisms Whereby Dietary Restriction Extends Healthspan: A Beneficial Type of Stress 96
Chapter 6. Mitochondrial Oxidative Stress and Caloric Restriction 114
Chapter 7. Understanding the Aging Fly Through Physiological Genetics 132
Chapter 8. Metabolism and Life span Determination in C. elegans 152
Chapter 9. Electron Transport and Life span in C. elegans 186
Chapter 10. Cellular Glucose Sensing, Energy Metabolism, and Aging in Saccharomyces cerevisiae 206
List of Contributors 224

Produkt-Details

• Erscheint lt. Verlag: 1.12.2003
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik
• ISBN-10: 0-08-049476-5 / 0080494765
• ISBN-13: 978-0-08-049476-0 / 9780080494760