Heteroaromatic Lipoxin A4 Analogues
Springer Berlin (Verlag)
978-3-642-24631-9 (ISBN)
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.
| Erscheint lt. Verlag | 5.1.2012 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XXII, 130 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 370 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Naturwissenschaften ► Chemie ► Physikalische Chemie | |
| Schlagworte | Aromatic Lipoxin A4 analogues • Lipoxin analogues phagocytosis of apoptotic PMN's • pro-inflammatory cytokine • Stable Lipoxins • Zirconium tetrachloride protection/deprotection me • Zirconium tetrachloride protection/deprotection methodology |
| ISBN-10 | 3-642-24631-1 / 3642246311 |
| ISBN-13 | 978-3-642-24631-9 / 9783642246319 |
| Zustand | Neuware |
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